Health Professionals Lab Research

National Institute of Health grants

The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, is the primary Federal agency for conducting and supporting medical research. NIH grants are awarded through a highly competitive grant process. The following are current and recently completed grants awarded to Legacy Health scientists.


Biomechanics

Michael Bottlang, PhD, Principal Investigator
R21AR053958
"Evaluating and improving an emergent technology for fixation of bone fractures"
07/01/2006 - 05/31/2008
Current Funding:  $207,240
Abstract

Trevor Lujan, PhD, Principal Investigator
R41AR059433
"A cost-effective bioreactor to advance functional tissue engineering of cartilage"
05/01/2010 - 04/30/2011
Current Funding: $100,175
Abstract 

Neurobiology — RS Dow Neurobiology Labs

Detlev Boison, PhD, Principal Investigator
R01NS058780
"Adenosine-releasing brain implants for epilepsy therapy"
01/01/2008 – 11/30/2011
Current Year Funding:  $323,409
Abstract 

Detlev Boison, PhD, Principal Investigator
R21NS057475
"Adenosine kinase as novel therapeutic target to prevent acquired epilepsy"
04/01/2008 – 03/31/2010
Current Year Funding:  $172,484
Abstract 

Detlev Boison, PhD, Principal Investigator
R21NS057538
"Adenosine kinase as therapeutic target to induce and maintain ischemic tolerance"
04/01/2008 – 03/31/2010
Current Year Funding:  $172,484
Abstract 

Detlev Boison, PhD, Principal Investigator
R01MH083973
"Adenosine and schizophrenia: mechanisms and therapies"
03/20/2009 - 01/31/2014
Current Year Funding:  $345,925
Abstract

Detlev Boison, PhD, Principal Investigator
R01NS061844
"Astrocyte dysfunction in epileptogenesis:  the role of adenosine"
04/15/2009 - 03/31/2013
Current Year Funding:  $310,472
Abstract

Theresa Lusardi, PhD, Principal Investigator
F32NS053257
"Sensitization in primary and secondary brain injury"
07/15/2005 – 07/14/2008
Current Year Funding:  $53,992
Abstract

Robert Meller, DPhil, Principal Investigator
R21NS054023
"Rapid ischemic tolerance:  Ubiquitin-mediated structural reorganization"
09/01/2006 – 06/30/2008
Current Year Funding:  $169,319
Abstract 

Robert Meller, DPhil, Principal Investigator
R01NS059588
"Rapid ischemic tolerance:  Synaptic re-organization and reduced excitotoxicity"
09/30/2008 – 08/31/2013
Current Year Funding:  $344,969
Abstract 

Julie A. Saugstad, PhD, Principal Investigator
R01 NS064270
"Role of MicroRNAs in ischemic tolerance"
05/01/2010 - 04/30/2013
Current Year Funding:  $306,000
Abstract 

Julie A. Saugstad, PhD, Principal Investigator
R21NS054220
"Role of MicroRNAs in ischemic tolerance"
08/02/2006 – 06/30/2008
Current Year Funding:  $203,182
Abstract 

Julie A. Saugstad, PhD, Principal Investigator
R01NS050221
"Neuroprotection by novel regulators of mGluR signaling"
12/16/2005 – 11/20/2009
Current Year Funding:  $304,773
Abstract 

Roger P. Simon, MD, Principal Investigator
R01NS047622
"Molecular determinants of epileptic brain injury"
07/01/2005 – 06/30/2009
Current Year Funding:  $339,799
Abstract 

Roger P. Simon, MD, Principal Investigator
R01NS039016
"Molecular mechanisms of seizure-induced brain injury"
07/01/1999 – 06/30/2010
Current Year Funding:  $339,864
Abstract 

Roger P. Simon, MD, Principal Investigator
R01NS050610
"Acid-sensing ion channels and ischemic brain injury"
05/24/2005 – 04/30/2010
Current Year Funding:  $333,286
Abstract 

Roger P. Simon, MD, Principal Investigator
P01NS035965
"Molecular mechanisms of ischemia"
03/01/1998 – 04/30/2008
Current Year Funding:  $1,247,891
Abstract

Roger P. Simon, MD, Principal Investigator
R01NS024728
"Cell excitation in ischemic brain injury"
07/01/1988 – 12/31/2010
Current Year Funding:  $343,006
Abstract 

Zhigang Xiong, MD, PhD, Principal Investigator
R01NS047506
"Acid-sensing channels as novel target for brain ischemia"
07/01/2004 – 05/31/2011
Current Year Funding:  $321,300
Abstract 

Zhigang Xiong, MD, PhD , Principal Investigator
R01NS049470
"A novel cation channel in excitatory neuronal injury"
04/01/2005 – 03/31/2009
Current Year Funding:  $322,594
Abstract 

An Zhou, PhD , Principal Investigator
R01NS046560
"Brain ischemia attenuates neuropeptide biosynthesis"
12/15/2004 – 11/30/2008
Current Year Funding:  $305,877
Abstract 
 
An Zhou, PhD , Principal Investigator
R21EY017345
"Neuropeptide processing and ischemic retina injury"
04/01/2006 – 03/31/2008
Current Year Funding:  $174,780
Abstract 

Neuromuscular

Jose Ochoa, MD, PhD, Principal Investigator
R01NS048932
"Primary C nociceptors and C sympathetics in CRPS"
06/15/2006 – 05/31/2010
Current Year Funding:   $383,118
Abstract

Neurotology

P. Ashley Wackym, MD, Principal Investigator
R01DC02971
"Molecular Basis of Vestibular Efferent Function"
07/01/1995 - 03/31/2011
Current Year Funding:  $343,506
Abstract 

Ophthalmology – Legacy Devers Research - Discoveries in Sight Research Laboratories

Claude F. Burgoyne, MD, Principal Investigator
R01EY01EY011610
"IOP-related force and failure in the optic nerve head"
07/01/1998 – 06/30/2016
Current Year Funding:  $783,403
Abstract 

Claude F. Burgoyne, MD, Principal Investigator
R01EY021281
"Optic nerve head SDOCT imaging in glaucoma"
12/01/2010 - 11/30/2014
Current Year Funding:  $382,500
Abstract 

Shaban Demirel, PhDPrincipal Investigator
R01EY019674
"Predicting the rate of progression in glaucoma"
09/30/09 - 08/31/2014
Current Year Funding:  $382,500
Abstract

J. Crawford Downs, PhD, Principal Investigator
R21EY018152
"3D reconstruction of optic nerve heads"
09/30/2007 – 08/03/2009
Current Year Funding:  $232,000
Abstract 

J. Crawford Downs, PhD,  
and Christopher A. Girkin, MD (Univ of Alabama Birmingham), Principal Investigators
R01EY018926
“Age-related changes in optic nerve head structure and biomechanics”   
04/01/2008 – 03/31/2012
Current Year Funding:  $343,283
Abstract 

J. Crawford Downs, PhD,  
and Christopher A. Girkin, MD (Univ of Alabama Birmingham), Principal Investigators
R01EY019333
"Racial Variations in Optic Nerve Head Structure and Biomechanics"  
12/01/2008 - 11/30/2011
Current Year Funding:  $320,085
Abstract 

Brad Fortune, OD, PhD, Principal Investigator
R01EY019327
"Axonal cytoskeletal changes in experimental glaucoma"
09/01/2009 - 08/31/2013
Current Year Funding:  $344,250
Abstract 

Brad Fortune, OD, PhD, Principal Investigator
1R21EY021311
"Imaging retinal astrocytes, ganglion cells and axonal transport in vivo "
08/01/2011 - 07/31/2013
Current Year Funding: $191,250
Abstract 

Stuart Gardiner, PhD, Principal Investigator
1R01EY020922
"Functional Testing for Glaucoma"
08/01/2011 - 06/30/2016
Current Year Funding: $364,480
Abstract

Steven L. Mansberger, MD, MPH, Principal Investigator
K23EY015501
"The Northwest tribal vision project"
06/01/2004 – 05/31/2009
Current Year Funding:  $248,020
Abstract 

Lin Wang, MD, Principal Investigator
R01EY019939
"Dynamic and Static Autoregulation Impairment in the Optic Nerve Head of Glaucoma"
08/01/2010 - 06/30/2015
Current Year Funding: $382,500
Abstract

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