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Scientists

Detlev Boison

Detlev Boison, Ph.D.

Robert S. Dow Chair of Neurology & Director of Neurobiology Research
Director of Basic and Translational Research, LRI
Adjunct Professor, Dept. of Neurology, OHSU
Adjunct Professor, Dept. of Neuroscience, WSU

Research Interests and Expertise
  • The biochemistry and epigenetics of epilepsy
  • Focal adenosine-augmentation therapies to treat epilepsy
  • Therapies for epilepsy prevention
  • Brain regeneration after traumatic brain injury and stroke
  • Comorbidities in Neurology
  • The adenosine hypothesis of schizophrenia
  • Role of adenosine in cancer
  • Metabolic therapies
Michael Bottlang

Michael Bottlang, Ph.D.

Director
Legacy Biomechanics Laboratory
Research Interests and Expertise
  • Bone fracture treatment
  • Prevention of traumatic brain injury
  • Mechano-active tissue engineering
Claude Burgoyne

Claude Burgoyne, M.D.

Senior Scientist
Van Buskirk Chair for Ophthalmic Research
Director, Optic Nerve Head Research Laboratory
Devers Eye Institute
Discoveries in Sight Research Laboratories

Research Interests and Expertise
  • Pathophysiology of glaucomatous optic nerve head damage
  • Optic nerve head biomechanics and blood flow
  • Optic nerve head aging
  • Optic nerve head imaging
  • Clinical examination of the optic nerve head tissues
Shaban Demirel

Shaban Demirel, O.D. Ph.D.

Senior Clinical Outcomes Research Scientist
Legacy Research Institute

Research Interests and Expertise
  • Clinical outcomes research
  • Data analysis and statistics
  • Machine learning and Artificial Intelligence applications in health care data
  • Clinical and basic psychophysics
  • Diagnostic device development
  • Glaucoma detection, progression and pathophysiology
Brad Fortune

Brad Fortune, O.D., Ph.D.

Associate Scientist and Director
Electrodiagnostic Services
Discoveries in Sight Research Laboratories

Research Interests and Expertise
  • Measurement of vision function in human glaucoma and experimental models of glaucoma
  • Electrophysiological assessment of vision function in human and experimental retinal disease models
  • Imaging retinal nerve fiber layer and optic disc structure, correlations with vision function
  • Glaucoma pathogenesis
Stuart Gardiner

Stuart Gardiner, Ph.D.

Assistant Scientist
Devers Eye Institute
Discoveries in Sight Research Laboratories
Research Interests and Expertise
  • Glaucoma Diagnostics
  • Functional testing in glaucoma
  • Structural testing in glaucoma
  • Glaucomatous pathophysiology
  • Measuring progression in glaucoma
  • Structure-function relationships in glaucoma
  • Data analysis and statistics
Charles Keller, MD

Charles Keller, MD

Adjunct Scientist, Legacy Research Institute
Scientific Director, Children’s Cancer Therapy Development Institute

Research Interests and Expertise
  • Childhood cancer
  • Sarcoma
  • Malignant brain tumors
  • Functional genomics
Steve Mansberger

Steven Mansberger, M.D., M.P.H.

Vice-Chair, Senior Scientist Director of Glaucoma Services and Ophthalmic Clinical Trials
Devers Eye Institute, Discoveries in Sight Research Laboratories

Research Interests and Expertise
  • Functional testing of glaucoma
  • Prevalence of eye disease in populations
  • Health behavior as it relates to glaucoma medication adherence
  • Eye drop administration
  • Biostatistics and epidemiology
R. Serene Perkins, MD

R. Serene Perkins, M.D.

Director, Surgical and Clinical Research
Director, Legacy Institute for Surgical Education and Innovation
Program Director, Legacy Tumor Bank
Legacy Research Institute

Research Interests and Expertise
  • Hepato-pancreato-biliary cancer and transplantation
  • Surgical team training and coaching
  • Clinical trials and outcomes research
  • Biorepository standards and best practices
  • Adenosine kinase gene therapy for cancer
James Rosenbaum

James T. Rosenbaum, M.D.

Chief of Ophthalmology and Chenoweth Chair  
Devers Eye Institute
Discoveries in Sight Research Laboratories

Clinical Vice President, Legacy Health 

Edward E Rosenbaum Professor of Inflammatory Diseases
Chair, Division of Arthritis & Rheumatic Diseases
Oregon Health & Science University 

Research Interests and Expertise
  • Uveitis

  • Ankylosing spondylitis

  • Orbital inflammatory disease

Lin Wang

Lin Wang, M.D., Ph.D.

Associate Scientist
Ocular Microcirculation Unit 
Devers Eye Institute 
Discoveries in Sight Research Laboratories

Research Interests and Expertise
  • Ocular blood flow autoregulation in retina and optic nerve
  • Ocular vascular pathology in glaucoma
  • Astrocytic regulation in ocular blood flow