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SWOG S1609

Trial

Clinical Trial Title

SWOG S1609

Trial Status

Open to Enrollment

Start Date

April 14, 2017

Location

Trial Type

Cancer (Oncology)

Specific Condition

Rare Tumors

Description

DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors

Eligibility Criteria

  • Patients are eligible under ONE of the following criteria:
  •     Patients must have histologically confirmed rare cancer
  •     FOR PATIENTS ENROLLED IN EAY131 "NCI-MATCH" PRIOR TO EAY131 ADDENDUM 10 ONLY: Patients must have histologically confirmed rare cancer identified in Section 18.1 t that did not have a match to a molecularly-guided therapy on EAY131 "NCI-MATCH" protocol or who are off protocol treatment on EAY131
  • Patients must be ≥ 18 years of age
  • Patients must have a Zubrod Performance Status of 0-2
  • No other prior malignancy is allowed except for the following:
  •     Adequately managed Stage I or II cancer from which the patient is currently in complete remission
  •     Any other cancer from which the patient has been disease free for one year
  •     Adequately managed Stage I or II follicular thyroid or prostate cancer is also eligible, wherein patient is not required to be in complete remission
  • Patients may have received either prior anti-CTLA4 or other prior anti-PD-1/anti-PD-L1 therapy, not both, provided that it is completed ≥ 4 weeks prior to registration
  • Patients with brain metastases or primary brain tumors must have completed treatment, surgery or radiation therapy ≥ 28 days prior to registration and have stable disease at time of registration. Metastatic brain parenchymal disease must have been treated and patient must be off steroids for 7 days prior to registration. Patients must have a CT or MRI scan of the brain to evaluate for CNS disease within 42 days prior to registration
  • Patients must not currently be receiving any other investigational agents or any other systemic anti-cancer therapy (including radiation, excluding RANKL inhibitors and bisphosphonates)

Please contact Legacy Oncology Research for additional study inclusion/exclusion information.

IRB Number

Central IRB

Principal Investigator Name

Jacqueline Vuky, MD

Contact Name

Oncology Clinical Research

Phone

503-413-8199

Contact Fax

503-413-6920

Contact E-Mail

oncologyresearch@lhs.org

Last Updated: Thursday, December 28, 2017 12:53:05 PM