Neurobiology

Neurobiology Publication Citations

Arranged chronologically descending.

Dubroqua S, Yee BK, Singer P.
Sensorimotor gating is disrupted by acute but not chronic systemic exposure to caffeine in mice.
Psychopharmacology (Berl). 2014 Apr 12. [Epub ahead of print]
Abstract

Lusardi TA, Murphy SJ, Phillips JI, Chen Y, Davis CM, Young JM, Thompson SJ, Saugstad JA.
MicroRNA responses to focal cerebral ischemia in male and female mouse brain.
Front Mol Neurosci. 2014 Feb 11;7:11. doi: 10.3389/fnmol.2014.00011. eCollection 2014.
Abstract

Singer P, Dubroqua S, Yee BK.
Forebrain glycine transporter 1 deletion enhances sensitivity to CS-US discontiguity in classical conditioning.
Neurobiol Learn Mem. 2014 Apr;110:47-54. doi: 10.1016/j.nlm.2014.01.014. Epub 2014 Jan 27.
Abstract

Shen HY, Sun H, Hanthorn MM, Zhi Z, Lan JQ, Poulsen DJ, Wang RK, Boison D.
Overexpression of adenosine kinase in cortical astrocytes and focal neocortical epilepsy in mice.
J Neurosurg. 2013 Nov 22. [Epub ahead of print]
Abstract

Yee BK, Singer P.
A conceptual and practical guide to the behavioural evaluation of animal models of the symptomatology and therapy of schizophrenia.
Cell Tissue Res. 2013 Oct;354(1):221-46. 
Abstract

Boison D.
Role of adenosine in status epilepticus: a potential new target?
Epilepsia. 2013 Sep;54 Suppl 6:20-2.
Williams-Karnesky RL, Sandau US, Lusardi TA, Lytle NK, Farrell JM, Pritchard EM, Kaplan DL, Boison D.
Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis.
J Clin Invest. 2013 Aug 1;123(8):3552-63.
Abstract

Boison D, Sandau US, Ruskin DN, Kawamura M Jr, Masino SA.
Homeostatic control of brain function - new approaches to understand epileptogenesis.
Front Cell Neurosci. 2013 Jul 16;7:109.
Abstract

Boison D.
Glowing feet control the blood of seizures.
Epilepsy Curr. 2013 May;13(3):122-3.

Boison D.
Adenosine kinase: exploitation for therapeutic gain.
Pharmacol Rev. 2013 Apr 16;65(3):906-43.
Abstract

Yee BK, Singer P.
A conceptual and practical guide to the behavioural evaluation of animal models of the symptomatology and therapy of schizophrenia.
Cell Tissue Res. 2013 Apr 12. [Epub ahead of print]
Abstract

Aronica E, Sandau US, Iyer A, Boison D.
Glial adenosine kinase - A neuropathological marker of the epileptic brain.
Neurochem Int. 2013 Feb 4. [Epub ahead of print]
Abstract

Boison D.
Adenosine and seizure termination: endogenous mechanisms.
Epilepsy Curr. 2013 Jan;13(1):35-7.

Singer P, Zhang CC, Boison D, Yee BK.
Dysregulation of brain adenosine is detrimental to the expression of conditioned freezing but not general Pavlovian learning.
Pharmacol Biochem Behav. 2013 Jan 2. [Epub ahead of print]
Abstract

Wu M, Sahbaie P, Zheng M, Lobato R, Boison D, Clark JD, Peltz G.
Opiate-induced changes in brain adenosine levels and narcotic drug responses.
Neuroscience. 2013 Jan 3;228:235-42.
Abstract

Singer P, Wei CJ, Chen JF, Boison D, Yee BK.
Deletion of striatal adenosine A(2A) receptor spares latent inhibition and prepulse inhibition but impairs active avoidance learning.
Behav Brain Res. 2012 Dec 28. [Epub ahead of print]
Abstract

Boison D.
A scaffold as a platform for new therapies?
Epilepsy Curr. 2012 Sep;12(5):172-3.
Abstract

Diógenes MJ, Neves-Tomé R, Fucile S, Martinello K, Scianni M, Theofilas P,
Lopatár J, Ribeiro JA, Maggi L, Frenguelli BG, Limatola C, Boison D, Sebastião AM.
Homeostatic Control of Synaptic Activity by Endogenous Adenosine is Mediated by Adenosine Kinase.
Cereb Cortex. 2012 Sep 20. [Epub ahead of print]
Abstract

Boison D.
Adenosine dysfunction in epilepsy.
Glia. 2012 Aug;60(8):1234-43.
Abstract

Steinhäuser C, Boison D.
Epilepsy: Crucial role for astrocytes.
Glia. 2012 Aug;60(8):1191.

Shen HY, Singer P, Lytle N, Wei CJ, Lan JQ, Williams-Karnesky RL, Chen JF, Yee BK, Boison D.
Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia.
J Clin Invest. 2012 Jul 2;122(7):2567-77.
Abstract

Lusardi TA, Thompson SJ, MacDonald IC, Lan JQ, Theofilas P, Saugstad JA.
Effect of (S)-3,5-DHPG on microRNA expression in mouse brain.
Exp Neurol. 2012 Jun;235(2):497-507. Epub 2012 Jan 28.
Abstract

Boison D.
A Breather for SUDEP.
Epilepsy Curr. 2012 May;12(3):111-2.

Singer P, McGarrity S, Shen HY, Boison D, Yee BK.
Working memory and the homeostatic control of brain adenosine by adenosine kinase.
Neuroscience. 2012 Apr 18. [Epub ahead of print]
Abstract

Boison D, Singer P, Shen HY, Feldon J, Yee BK.
Adenosine hypothesis of schizophrenia - Opportunities for pharmacotherapy.
Neuropharmacology. 2012 Mar;62(3):1527-43. Epub 2011 Feb 17.
Abstract

Li T, Lytle N, Lan JQ, Sandau US, Boison D.
Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: A first step in epileptogenesis?
Glia. 2012 Jan;60(1):83-95.
Abstract

de Groot M, Iyer A, Zurolo E, Anink J, Heimans JJ, Boison D, Reijneveld JC, Aronica E.
Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy.
Epilepsia. 2012 Jan;53(1): 58-66.
Abstract

Lusardi TA, Lytle NK, Szybala C, Boison D.
Caffeine prevents acute mortality after TBI in rats without increased morbidity.
Exp Neurol. 2011 Dec 27. [Epub ahead of print]
Abstract

Boison D.
The sound of noninvasive seizure control.
Epilepsy Curr. 2011 Nov;11(6):196-7.

Boison D.
After the storm: from windswept to spiny trees.
Epilepsy Curr. 2011 Sep;11(5):155-6.

Lazarus M, Shen HY, Cherasse Y, Qu WM, Huang ZL, Bass CE, Winsky-Sommerer R, Semba K, Fredholm BB, Boison D, Hayaishi O, Urade Y, Chen JF.
Arousal Effect of Caffeine Depends on Adenosine A2A Receptors in the Shell of the Nucleus Accumbens.
J Neurosci. 2011 Jul 6;31(27):10067-10075.
Abstract

Boison D, Masino SA, Geiger JD.
Homeostatic bioenergetic network regulation - a novel concept to avoid pharmacoresistance in epilepsy.
Expert Opin Drug Discov. 2011 Jul;6(7):713-724.
Abstract

Masino SA, Li T, Theofilas P, Sandau US, Ruskin DN, Fredholm BB, Geiger JD, Aronica E, Boison D.
A ketogenic diet suppresses seizures in mice through adenosine A1 receptors.
J Clin Invest. 2011 Jul 1;121(7):2679-83. Epub 2011 Jun 23.
Abstract

Wei CJ, Singer P, Coelho J, Boison D, Feldon J, Yee BK, Chen JF.
Selective inactivation of adenosine A2A receptors in striatal neurons enhances working memory and reversal learning.
Learn Mem. 2011 Jun 21;18(7):459-74.
Abstract

Aronica E, Zurolo E, Iyer A, de Groot M, Anink J, Carbonell C, van Vliet EA, Baayen JC, Boison D, Gorter JA.
Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy.
Epilepsia. 2011 Jun 2. [Epub ahead of print]
Abstract

Dubroqua S, Boison D, Feldon J, Möhler H, Yee BK.
Examining the sex- and circadian dependency of a learning phenotype in mice with glycine transporter 1 deletion in two Pavlovian conditioning paradigms.
Neurobiol Learn Mem. 2011 May 10. [Epub ahead of print]
Abstract

Boison D.
Modulators of nucleoside metabolism in the therapy of brain diseases.
Curr Top Med Chem. 2011;11(8):1068-86.
Abstract

Möhler H, Boison D, Singer P, Feldon J, Pauly-Evers M, Yee BK.
Glycine transporter 1 as a potential therapeutic target for schizophrenia-related symptoms: Evidence from genetically modified mouse models and pharmacological inhibition.
Biochem Pharmacol. 2011 May 1;81(9):1065-77.
Abstract

Ceman S, Saugstad J.
MicroRNAs: Meta-controllers of gene expression in synaptic activity emerge as genetic and diagnostic markers of human disease.
Pharmacol Ther. 2011 Apr;130(1):26-37. Epub 2011 Jan 20.]
Abstract

Shen HY, Lusardi TA, Williams-Karnesky RL, Lan JQ, Poulsen DJ, Boison D.
Adenosine kinase determines the degree of brain injury after ischemic stroke in mice.
J Cereb Blood Flow Metab. 2011 Mar 23. [Epub ahead of print]
Abstract

Theofilas P, Brar S, Stewart KA, Shen HY, Sandau US, Poulsen D, Boison D.
Adenosine kinase as a target for therapeutic antisense strategies in epilepsy.
Epilepsia. 2011 Mar;52(3):589-601.
Abstract

Coombes E, Jiang J, Chu XP, Inoue K, Seeds J, Branigan D, Simon RP, Xiong ZG.
Pathophysiologically Relevant Levels of Hydrogen Peroxide Induce Glutamate-Independent Neurodegeneration That Involves Activation of Transient Receptor Potential Melastatin 7 Channels.
Antioxid Redox Signal. 2011 Jan 26. [Epub ahead of print]
Abstract

Boison D.
Methylxanthines, seizures, and excitotoxicity.
Handb Exp Pharmacol. 2011;(200):251-66.
Abstract

Dubroqua S, Singer P, Boison D, Feldon J, Möhler H, Yee BK.
Impacts of forebrain neuronal glycine transporter 1 disruption in the senescent brain: Evidence for age-dependent phenotypes in pavlovian learning.
Behav Neurosci. 2010 Nov 1. [Epub ahead of print]
Abstract

Li M, Kratzer E, Inoue K, Simon RP, Xiong ZG.
Developmental change in the electrophysiological and pharmacological properties of acid-sensing ion channels in CNS neurons.
J Physiol. 2010 Oct 15;588(Pt 20):3883-900. Epub 2010 Aug 19.
Abstract

Pritchard EM, Valentin T, Boison D, Kaplan DL.
Incorporation of proteinase inhibitors into silk-based delivery devices for enhanced control of degradation and drug release.
Biomaterials. 2010 Oct 13. [Epub ahead of print]
Abstract

Palchykova S, Winsky-Sommerer R, Shen HY, Boison D, Gerling A, Tobler I.
Manipulation of adenosine kinase affects sleep regulation in mice.
J Neurosci. 2010 Sep 29;30(39):13157-65.
Abstract

Saugstad JA.
MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration.
J Cereb Blood Flow Metab. 2010 Sep;30(9):1564-76.
Abstract

Boison D
Inhibitory RNA in epilepsy: Research tools and therapeutic perspectives (Critical Review and Invited Commentary)
Epilepsia. 2010 Sep;51(9):1659-68.
Abstract

Van Dycke A, Raedt R, Verstraete A, Theofilas P, Wadman W, Vonck K, Boison D, Boon P.
Astrocytes derived from fetal neural progenitor cells as a novel source for therapeutic adenosine delivery.
Seizure. 2010 Sep;19(7):390-6.
Abstract

Vlajkovic SM, Guo CX, Dharmawardana N, Wong AC, Boison D, Housley GD, Thorne PR.
Role of adenosine kinase in cochlear development and response to noise.
J Neurosci Res. 2010 Sep;88(12):2598-609.
Abstract

Boison D, Chen JF, Fredholm BB.
Adenosine signaling and function in glial cells.
Cell Death Differ. 2010 Jul;17(7):1071-82.
Abstract

Singer P, Boison D, Möhler H, Feldon J, Yee BK.
Modulation of sensorimotor gating in prepulse inhibition by conditional brain glycine transporter 1 deletion in mice.
Eur Neuropsychopharmacol. 2010 Jul 18. [Epub ahead of print]
Abstract

Li M, Inoue K, Branigan D, Kratzer E, Hansen JC, Chen JW, Simon RP, Xiong ZG.
Acid-sensing ion channels in acidosis-induced injury of human brain neurons.
J Cereb Blood Flow Metab. 2010 Jun;30(6):1247-60. Epub 2010 Mar 10.
Abstract

Pritchard EM, Szybala C, Boison D, Kaplan DL.
Silk fibroin encapsulated powder reservoirs for sustained release of adenosine.
J Control Release. 2010 Jun 1;144(2):159-67.
Abstract

Chai S, Li M, Branigan D, Xiong ZG, Simon RP.
Activation of acid-sensing ion channel 1a (ASIC1a) by surface trafficking.
J Biol Chem. 2010 Apr 23;285(17):13002-11.
Abstract

Lusardi TA, Farr CD, Faulkner CL, Pignataro G, Yang T, Lan J, Simon RP, Saugstad JA.
Ischemic preconditioning regulates expression of microRNAs and a predicted target, MeCP2, in mouse cortex.
J Cereb Blood Flow Metab. 2010 Apr;30:744-56.
Abstract

Ren G, Boison D.
Engineering human mesenchymal stem cells to release adenosine using miRNA technology.
Methods Mol Biol. 2010;650:225-40.
Abstract

Stapels M, Piper C, Yang T, Li M, Stowell C, Xiong ZG, Saugstad J, Simon RP, Geromanos S, Langridge J, Lan JQ, Zhou A.
Polycomb group proteins as epigenetic mediators of neuroprotection in ischemic tolerance.
Sci Signal. 2010 Mar 2;3(111):ra15
Abstract

Shen HY, Li T, Boison D.
A novel mouse model for sudden unexpected death in epilepsy (SUDEP): Role of impaired adenosine clearance.
Epilepsia. 2010 Mar;51:465-8.
Abstract

Inoue K, Branigan D, Xiong ZG.
Zinc-induced neurotoxicity mediated by transient receptor potential melastatin 7 channels.
J Biol Chem. 2010 Mar 5;285(10):7430-9.
Abstract

Boison D.
Adenosine dysfunction and adenosine kinase in epileptogenesis.
Open Neurosci J. 2010 Jan 1;4:93-101.
Abstract

Boison D, Stewart KA.
Therapeutic epilepsy research: from pharmacological rationale to focal adenosine augmentation.
Biochem Pharmacol. 2009 Dec 15;78(12):1428-37. Epub 2009 Aug 12.
Abstract

Singer P, Boison D, Möhler H, Feldon J, Yee BK.
Deletion of glycine transporter 1 (GlyT1) in forebrain neurons facilitates reversal learning: enhanced cognitive adaptability?
Behav Neurosci. 2009 Oct;123(5):1012-27.
Abstract

Szybala C, Pritchard EM, Lusardi TA, Li T, Wilz A, Kaplan DL, Boison D.
Antiepileptic effects of silk-polymer based adenosine release in kindled rats.
Exp Neurol. 2009 Sep;219(1):126-35. Epub 2009 May 19.
Abstract

Shen HY, Chen JF.
Adenosine A(2A) receptors in psychopharmacology: modulators of behavior, mood and cognition.
Curr Neuropharmacol. 2009 Sep;7(3):195-206.
Abstract

Boison D.
Adenosine-based modulation of brain activity.
Curr Neuropharmacol. 2009 Sep;7(3):158-9.

Inoue K, Xiong ZG.
Silencing TRPM7 promotes growth/proliferation and nitric oxide production of vascular endothelial cells via the ERK pathway.
Cardiovasc Res. 2009 Aug 1;83(3):547-57. Epub 2009 May 18.
Abstract

Boison D.
Adenosine augmentation therapies (AATs) for epilepsy: prospect of cell and gene therapies.
Epilepsy Res. 2009 Aug;85(2-3):131-41. Epub 2009 May 9.

Meller R.
The role of the ubiquitin proteasome system in ischemia and ischemic tolerance.
Neuroscientist. 2009 Jun;15(3):243-60. Epub 2009 Jan 30.
Abstract

Loftus LT, Gala R, Yang T, Jessick VJ, Ashley MD, Ordonez AN, Thompson SJ, Simon RP, Meller R.
Sumo-2/3-ylation following in vitro modeled ischemia is reduced in delayed ischemic tolerance.
Brain Res. 2009 May 26;1272:71-80. Epub 2009 Mar 28.
Abstract

Boison D.
Engineered adenosine-releasing cells for epilepsy therapy: human mesenchymal stem cells and human embryonic stem cells.
Neurotherapeutics. 2009 Apr;6(2):278-83.
Abstract

Li T, Ren G, Kaplan DL, Boison D.
Human mesenchymal stem cell grafts engineered to release adenosine reduce chronic seizures in a mouse model of CA3-selective epileptogenesis.
Epilepsy Res. 2009 Apr;84(2-3):238-41. Epub 2009 Feb 12.
Abstract

Zhan S, Zhao H, J White A, Minami M, Pignataro G, Yang T, Zhu X, Lan J, Xiong Z, Steiner DF, Simon RP, Zhou A.
Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains.
J Cereb Blood Flow Metab. 2009 Apr;29(4):698-706. Epub 2009 Jan 14
Abstract

Singer P, Yee BK, Feldon J, Iwasato T, Itohara S, Grampp T, Prenosil G, Benke D, Möhler H, Boison D.
Altered Mnemonic Functions and Resistance to NMDA Receptor Antagonism by Forebrain Conditional Knockout of Glycine Transporter 1.
Neuroscience. 2009 Mar 27. [Epub ahead of print]

Etherington LA, Patterson GE, Meechan L, Boison D, Irving AJ, Dale N, Frenguelli BG.
Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus. Neuropharmacology. 2009 Feb;56(2):429-37. Epub 2008 Oct 10. 

Boison D.
Astrogliosis and adenosine kinase: a glial basis of epilepsy.
Future Neurol. 2008 3(3):221-224; Editorial

Möhler H, Rudolph U, Boison D, Singer P, Feldon J, Yee BK. 
Regulation of cognition and symptoms of psychosis: Focus on GABAA receptors and glycine transporter 1.
Pharmacol Biochem Behav. 2008 90(1):58-64; Review

Maysami S, Lan JQ, Minami M, Simon RP.
Proliferating progenitor cells: a required cellular element for induction of ischemic tolerance in the brain.
J Cereb Blood Flow Metab. 2008 Jun;28(6):1104-13.

Wilz A, Pritchard EM, Li T, Lan JQ, Kaplan DL, Boison D. 
Silk polymer based adenosine release: therapeutic potential for epilepsy.
Biomaterials 2008 29:3609-3616.

Shen H-Y, Coelho JE, Ohtsuka N, Canas PM, Day Y-J, Huang Q-Y, Rebola N, Yu L, Boison D, Cunha RA, Linden J, Tsien JZ, Chen J-F. 
A critical role of the adenosine A2A receptor in extra-striatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum- and forebrain-A2A receptor knockouts.
J Neurosci. 2008 28(12):2970-2975

Meller R, Thompson SJ, Lusardi TA, Ordonez AN, Ashley MD, Jessick V, Wang W, Torrey DJ, Henshall DC, Gafken PR, Saugstad JA, Xiong ZG, Simon RP. (2008)
Ubiquitin proteasome-mediated synaptic reorganization: a novel mechanism underlying rapid ischemic tolerance.
J Neurosci. 2008 Jan 2;28(1):50-9. 

Li T, Ren G, Lusardi T, Wilz A, Lan JQ, Iwasato T, Itohara S, Simon RP, Boison D. 
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice.
J Clin Invest.  2008 118:571-582.

Boison D.
The adenosine kinase hypothesis of epileptogenesis.
Prog Neurobiol.  2008 84:249-62. Review.

Thompson SJ, Loftus LT, Ashley MD, Meller R.
Ubiquitin-proteasome system as a modulator of cell fate.
Curr Opin Pharmacol. 2008 8:90-5.

Xiong ZG, Pignataro G, Li M, Chang SY, Simon RP.
Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases.
Curr Opin Pharmacol. 2008 8:2-7.

Pignataro G, Meller R, Inoue K, Ordonez AN, Ashley MD, Xiong Z, Simon RP.
In vivo and in vitro characterization of a novel neuroprotective strategy for stroke: ischemic postconditioning.
J Cereb Blood Flow Metab. 2008 28:232-41.

Boison D. 
Adenosine as a neuromodulator in neurological diseases.
Curr Opin Pharmacol. 2008  8:2-7.  Review.

Pignataro G, Maysami S, Studer FE, Wilz A, Simon RP, Boison D.
Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism.
J Cereb Blood Flow Metab. 2008 28:17-23.

Sato Y, Meller R, Yang T, Taki W, Simon RP.
Stereo-selective neuroprotection against stroke with vitamin A derivatives.
Brain Res. 2008 Nov 19;1241:188-92

Boison D. 
Adenosine as a modulator of brain activity.
Drug News Persp.  2007 20:607-11.  Review

Li T, Lan JQ, Fredholm B, Simon RP, Boison D.
Adenosine dysfunction in astrogliosis: cause for seizure generation?
Neuron Glia Biol. 2007 3:353-366.

Ren G, Li T, Lan JQ, Wilz A, Simon RP, Boison D.  (2007)
Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: A novel perspective for seizure control.
Exp Neurol. 2007 208:26-37.

Yee BK, Singer P, Chen JF, Feldon J, Boison D. 
Transgenic overexpression of adenosine kinase in brain leads to multiple learning impairments and altered sensitivity to psychomimetic drugs.
Eur J Neurosci. 2007 26:3237-3252

Wu NL, Boison D. 
Adenosine kinase expression modulates expression of myelin proteolipid protein.
The Open Neuroscience Journal. 2007 1:15-19

Singer P, Boison D, Mohler H, Feldon J, Yee BK.
Enhanced recognition memory following glycine transporter 1 deletion in forebrain neurons.
Behav Neurosci. 2007 Oct;121(5):815-25.

Bottlang M, Sommers MB, Lusardi TA, Miesch JJ, Simon RP, Xiong ZG.
Modeling neural injury in organotypic cultures by application of inertia-driven shear strain.
J Neurotrauma. 2007 Jun;24(6):1068-77.

Hey JG, Chu XP, Seeds J, Simon RP, Xiong ZG.
Extracellular zinc protects against acidosis-induced injury of cells expressing Ca2+-permeable acid-sensing ion channels.
Stroke. 2007 Feb;38(2 Suppl):670-3.

Murphy B, Dunleavy M, Shinoda S, Schindler C, Meller R, Bellver-Estelles C, Hatazaki S, Dicker P, Yamamoto A, Koegel I, Chu X, Wang W, Xiong Z, Prehn J, Simon R, Henshall D.
Bcl-w Protects Hippocampus during Experimental Status Epilepticus.
Am J Pathol. 2007 Aug 16; [Epub ahead of print] 

Pignataro G, Simon RP, Xiong ZG.
Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia.
Brain. 2007 Jan;130(Pt 1):151-8. 

Pignataro G, Studer FE, Wilz A, Simon RP, Boison D.
Neuroprotection in ischemic mouse brain induced by stem cell-derived brain implants.
J Cereb Blood Flow Metab. 2007 May;27(5):919-27. 
 
Rosenzweig HL, Minami M, Lessov NS, Coste SC, Stevens SL, Henshall DC, Meller R,  Simon RP, Stenzel-Poore MP.
Endotoxin preconditioning protects against the cytotoxic effects of TNFalpha after stroke: a novel role for TNFalpha in LPS-ischemic tolerance.
J Cereb Blood Flow Metab. 2007 Feb 28; [Epub ahead of print] 

Xu TL, Xiong ZG.
Dynamic regulation of acid-sensing ion channels by extracellular and intracellular modulators.
Curr Med Chem. 2007;14(16):1753-63.

Chai S, Li M, Lan J, Xiong ZG, Saugstad JA, Simon RP.
A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid sensing ion channels ASIC1a and ASIC2a.
J Biol Chem. 2007 Jun 4; [Epub ahead of print]

Boison D. (2007)
Cell and gene therapies for refractory epilepsy.
Current Neuropharmacology. 2007;5(2):115-125.

Li T, Steinbeck JA, Lusardi T, Koch P, Lan JQ, Wilz A, Segschneider M, Simon RP, Brüstle O, Boison D.
Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants.
Brain. 2007;130: 1276-1288

Boison D. 
Adenosine-based cell therapy approaches for pharmacoresistant epilepsies.
Neurodegener Dis. 2007;4(1): 28-33.

Hey JG, Chu XP, Seeds J, Simon RP, Xiong ZG.
Extracellular zinc protects against acidosis-induced injury of cells expressing Ca2+-permeable acid-sensing ion channels.
Stroke. 2007 Feb;38(2 Suppl):670-3.

Pignataro G, Simon RP, Boison D.
Transgenic overexpression of adenosine kinase aggravates cell death in ischemia.
J Cereb Blood Flow Metab. 2007 Jan;27(1):1-5. 

Pignataro G, Simon RP, Xiong ZG.
Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia.
Brain. 2007 Jan;130(Pt 1):151-8. 

Simon RP.
Genomics of ischemia: introduction.
Stroke. 2007 Feb;38(2):677-9.

Simon RP.
25th princeton conference on cerebrovascular disease: preface.
Stroke. 2007 Feb;38(2):613.

Xiong ZG, Chu XP, Simon RP.
Acid sensing ion channels--novel therapeutic targets for ischemic brain injury.
Front Biosci. 2007 Jan 1;12:1376-86. 

Boison D.
Adenosine kinase, epilepsy and stroke: mechanisms and therapies.
Trends Pharmacol Sci. 2006 Oct 20; [Epub ahead of print]  

Chu XP, Close N, Saugstad JA, Xiong ZG.
ASIC1a-specific modulation of acid-sensing ion channels in mouse cortical neurons by redox reagents.
J Neurosci. 2006 May 17;26(20):5329-39.

Fedele DE, Li T, Lan JQ, Fredholm BB, Boison D.
Adenosine A1 receptors are crucial in keeping an epileptic focus localized.
Exp Neurol. 2006;200(1):184-90.

MacDonald JF, Xiong ZG, Jackson MF.
Paradox of Ca2+ signaling, cell death and stroke.
Trends Neurosci. 2006 Feb;29(2):75-81
.  
Meller R, Clayton C, Torrey DJ, Schindler CK, Lan JQ, Cameron JA, Chu XP, Xiong ZG, Simon RP, Henshall DC.
Activation of the caspase 8 pathway mediates seizure-induced cell death in cultured hippocampal neurons.
Epilepsy Res. 2006 Jul;70(1):3-14. Epub 2006 Mar 20.

Meller R, Cameron JA, Torrey DJ, Clayton CE, Ordonez AN, Henshall DC, Minami M, Schindler CK, Saugstad JA, Simon RP. 
Rapid degradation of bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons.
J Biol Chem. 2006 Mar 17;281(11):7429-36.

Pignataro G, Studer FE, Wilz A, Simon RP, Boison D.
Neuroprotection in ischemic mouse brain induced by stem cell-derived brain implants.
J Cereb Blood Flow Metab. 2006 Nov 22; [Epub ahead of print]   

Schindler CK, Heverin M, Henshall DC.
Isoform- and subcellular fraction-specific differences in hippocampal 14-3-3 levels following experimentally evoked seizures and in human temporal lobe epilepsy.
J Neurochem. 2006 Oct;99(2):561-9.

Simon RP.
Acidotoxicity trumps excitotoxicity in ischemic brain.
Arch Neurol. 2006 Oct;63(10):1368-71.

Simon R, Xiong Z.
Acidotoxicity in brain ischaemia.
Biochem Soc Trans. 2006 Dec;34(Pt 6):1356-61. 

Studer FE, Fedele DE, Marowsky A, Schwerdel C, Wernli K, Vogt K,FritschyJM, Boison D.
Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme.
Neuroscience. 2006;142(1):125-37.

Uebersax L, Fedele DE, Schumacher C, Kaplan DL, Merkle HP, Boison D, Meinel L.
The support of adenosine release from adenosine kinase deficient ES cells by silk substrates.
Biomaterials. 2006;27(26):4599-607.

Wang WZ, Chu XP, Li MH, Seeds J, Simon RP, Xiong ZG.
Modulation of Acid-sensing Ion Channel Currents, Acid-induced Increase of Intracellular Ca2+, and Acidosis-mediated Neuronal Injury by Intracellular pH. J
Biol Chem. 2006 Sep 29;281(39):29369-78. Epub 2006 Aug 1. 

Xiong ZG, Chu XP, Simon RP.
Ca(2+)-Permeable Acid-sensing Ion Channels and Ischemic Brain Injury.
J Membr Biol. 2006 Apr 17; [Epub ahead of print]  

Yamamoto A, Murphy N, Schindler CK, So NK, Stohr S, Taki W, Prehn JH, Henshall DC.
Endoplasmic reticulum stress and apoptosis signaling in human temporal lobe epilepsy.
J Neuropathol Exp Neurol. 2006 Mar;65(3):217-25.  

Yamamoto A, Schindler CK, Murphy BM, Bellver-Estelles C, So NK, Taki W, Meller R, Simon RP, Henshall DC.
Evidence of tumor necrosis factor receptor 1 signaling in human temporal lobe epilepsy.
Exp Neurol. 2006 Aug 16; [Epub ahead of print]     

Yee BK, Balic E, Singer P, Schwerdel C, Grampp T, Gabernet L,Knuesel I, Benke D, Feldon J, Mohler H, Boison D. 
Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile.
J Neurosci. 2006 Dec;26(12):3169-81.    

Henshall DC, Simon RP.
Epilepsy and apoptosis pathways.
J Cereb Blood Flow Metab. 2005 Dec;25(12):1557-72.  Review.

Meller R, Minami M, Cameron JA, Impey S, Chen D, Lan JQ, Henshall DC, Simon RP.
CREB-mediated Bcl-2 protein expression after ischemic preconditioning.
J Cereb Blood Flow Metab. 2005 Feb;25(2):234-46. 

Meller R, Stevens SL, Minami M, Cameron JA, King S, Rosenzweig H, Doyle K, Lessov NS, Simon RP, Stenzel-Poore MP.
Neuroprotection by osteopontin in stroke.
J Cereb Blood Flow Metab. 2005 Feb;25(2):217-25.

Schindler CK, Pearson EG, Bonner HP, So NK, Simon RP, Prehn JH, Henshall DC.
Caspase-3 cleavage and nuclear localization of caspase-activated DNase in human temporal lobe epilepsy.
J Cereb Blood Flow Metab. 2005 Aug 24; [Epub ahead of print]

Chu XP, Wemmie JA, Wang WZ, Zhu XM, Saugstad JA, Price MP, Simon RP, Xiong ZG.
Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels.
J Neurosci. 2004 Oct 6;24(40):8678-89. 

Farr CD, Gafken PR, Norbeck AD, Doneanu CE, Stapels MD, Barofsky DF, Minami M, Saugstad JA.
Proteomic analysis of native metabotropic glutamate receptor 5 protein complexes reveals novel molecular constituents.
J Neurochem.  2004 Oct;91(2):438-50.  

Rosenzweig HL, Lessov NS, Henshall DC, Minami M, Simon RP, Stenzel-Poore MP.
Endotoxin Preconditioning Prevents Cellular Inflammatory Response During Ischemic Neuroprotection in Mice.
Stroke. 2004 Sep 16   [Epub ahead of print] 

Saugstad JA, Roberts JA, Dong J, Zeitouni S, Evans RJ.
Analysis of the membrane topology of the acid-sensing ion
channel 2a.
J Biol Chem. 2004 Dec 31;279:55514-9.  

Stenzel-Poore MP, Stevens SL, Simon RP.
Genomics of preconditioning.
Stroke. 2004 Sep 30   [Epub ahead of print]

Xiong ZG, Zhu XM, Chu XP, Minami M, Hey J, Wei WL, MacDonald JF, Wemmie JA, Price MP, Welsh MJ, Simon RP.
Neuroprotection in ischemia; blocking calcium-permeable Acid-sensing ion channels.
Cell.  2004 Sep 17;118(6):687-98. 

Zhou A, Minami M, Zhu X, Bae S, Minthorne J, Lan J, Xiong ZG, Simon RP.
Altered biosynthesis of neuropeptide processing enzyme carboxypeptidase E after brain ischemia: molecular mechanism and implication.
J Cereb Blood Flow Metab.  2004 Jun;24(6):612-22.

Araki T, Shinoda S, Schindler CK, Quan-Lan J, Meller R, Taki W, Simon RP, Henshall DC.
Expression, interaction, and proteolysis of death-associated protein kinase and p53 within vulnerable and resistant hippocampal subfields following seizures.
Hippocampus. 2004;14(3):326-36.

Henshall DC, Schindler CK, So NK, Lan JQ, Meller R, Simon RP.
Death-associated protein kinase expression in human temporal lobe epilepsy.
Ann Neurol. 2004 Apr;55(4):485-94.

Schindler CK, Shinoda S, Simon RP, Henshall DC.
Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat.
Neurosci Lett. 2004 Feb 19;356(3):163-6.

Shinoda S, Araki T, Lan JQ, Schindler CK, Simon RP, Taki W, Henshall DC.
Development of a model of seizure-induced hippocampal injury with features of programmed cell death in the BALB/c mouse.
J Neurosci Res. 2004 Apr 1;76(1):121-8.

Shinoda S, Schindler CK, Meller R, So NK, Araki T, Yamamoto A, Lan JQ, Taki W, Simon RP, Henshall DC.
Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy.
J Clin Invest. 2004 Apr;113(7):1059-68.

Henshall DC, Araki T, Schnidler CK, Shinoda S, Lan JQ, Simon RP.
Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures.
J. Neurochem. 2003 Sep;86: 1260-1270.

Stenzel-Poore MP, Stevens SL, Xiong Z, Lessov NS, Harrington CA, Mori M, Meller R, Rosenzweig HL, Tobar E, Shaw TE, Chu X, Simon RP.
Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states.
Lancet. 2003 Sep 27;362(9389):1028-37.

Chen D, Jin K, Kawaguchi K, Nakayama M, Zhou X, Xiong Z, Zhou A, Mao XO, Greenberg DA, Graham SH, Simon RP.
Ero1-L, an ischemia-inducible gene from rat brain with homology to global ischemia-induced gene 11 (Giig11), is localized to neuronal dendrites by a dispersed identifier (ID) element-dependent mechanism.
J Neurochem 2003 May;85(3):670-9.

Chen D, Minami M, Henshall DC, Meller R, Kisby G, Simon RP.
Upregulation of mitochondrial base-excision repair capability within rat brain after brief ischemia.
J Cereb Blood Flow Metab 2003 Jan;23(1):88-98.

Chu XP, Zhu XM, Wei WL, Li GH, Simon RP, MacDonald JF, Xiong ZG.
Acidosis decreases low Ca2+ -induced neuronal excitation by inhibiting the activity of calcium-sensing cation channels in cultured mouse hippocampal neurons.
J Physiol. 2003 Jul 15;550(Pt 2):385-99.

Dirnagl U, Simon RP, Hallenbeck JM.
Ischemic tolerance and endogenous neuroprotection.
Trends Neurosci. 2003 May;26(5):248-54.

Doyle KP, Simon RP, Snyder A, Stenzel-Poore MP.
Working with GFP in the brain.
Biotechniques 2003;34:492-494.

Liou AK, Clark RS, Henshall DC, Yin XM, Chen J.
To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways.
Prog Neurobiol 2003 Feb;69(2):103-42.

Meller R, Schindler CK, Chu XP, Xiong ZG, Cameron JA, Simon RP, Henshall DC.
Seizure-like activity leads to the release of BAD from 14-3-3 protein and cell death in hippocampal neurons in vitro.
Cell Death Differ 2003 May;10(5):539-47.

Shinoda S, Skradski SL, Araki T, Schindler CK, Meller R, Lan JQ, Taki W, Simon RP, Henshall DC.
Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death.
Eur J Neurosci. 2003 Jun;17(10):2065-76.

Shinoda S, Schindler CK, Quan-Lan J, Saugstad JA, Taki W, Simon RP, Henshall DC.
Interaction of 14-3-3 with Bid during seizure-induced neuronal death.
J Neurochem. 2003 Jul;86(2):460-9.

Sun Y, Jin K, Clark KR, Peel A, Mao XO, Chang Q, Simon RP, Greenberg DA.
Adeno-associated virus-mediated delivery of BCL-w gene improves outcome after transient focal cerebral ischemia.
Gene Ther 2003 Jan;10(2):115-22.