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5-HYDROXYINDOLEACETIC ACID, URINE

Mnemonic

HIAA

Synonym

5-HIAA

Specimen Collection Requirements

Patient Preparation

If possible, patients should abstain from medications, over-the-counter drugs and herbal remedies for at least 72 hours before the test. Foods rich in serotonin (avocados, bananas, eggplant, pineapple, plums, tomatoes, walnuts) may affect metabolism of serotonin and also must be avoided at least 72 hours before and during collection of urine for HIAA.

Collect

Urine, 24-hour or random collection

Handling

Refrigeration is the most important aspect of specimen preservation. Urine, a 5 mL aliquot from a well-mixed 24-hour or random collection at 2-8°C. State the total volume on the tube and requisition.

Preferred Volume

5.0 mL

Minimum Volume

1.0 mL

Transport

Refrigerated

Rejection Criteria

Room temperature unacceptable

Stability

Ambient: Unacceptable; Refrigerated: 7 days; Frozen: 2 weeks

Testing Information

Performed

Sun - Sat

Reported

3-7 days

Method

Quantitative High Performance Liquid Chromatography - Tandem Mass Spectrometry

Referral Lab

ARUP (80420)

Reference Values

Reference Values

Interpretation provided.

Comments

Foods and Medication associated with HIAA Results:

Decreased HIAA:  Aspirin, Chlorpromazine (Thorazine), corticotropin, dihydroxyphenylacetic acid, ethanol, gentistic acid, homogentistic acid, hydrazine derivatives, imipramine (Tolfranil®), isocarboxazid (Marplan), keto acids, levodopa, MAO inhibitors, methenamine, methyldopa (Aldomet®), perchlorperazine, phenothiazines (Compazine®), promazine, promethazine (Mepergan®)

Increased HIAA:  Acetaminophen, acetanilide, caffeine, coumaric acid, diazepam (Valium®), ephedrine, fluorouracil, glycerol guaiacolate (Guaifeensin), melphalan (Alkeran®), mephenesin, Methamphetamine (Desoxyn), methocarbamol (Robaxin®), naproxen, micotine, phenacetin, phenmetrazine, phenobarbital, phentolamine, rauwolfia, reserpine

CPT Codes

83497

Last Updated: Wednesday, September 20, 2017 03:22:51 PM


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