CATECHOLAMINES, URINE FRACTIONATED FREE
Adrenaline - Dopamine - Epinephrine - Noradrenaline - Norepinephrine
Medications which may physiologically interfere with catecholamines and metabolites include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, carbidopa-levodopa (Sinemet®), clonidine, dexamethasone, diuretics (in doses sufficient to deplete sodium), ethanol, isoproterenol, methyldopa (Aldomet®), MAO inhibitors, nicotine, nose drops, propafenone (Rythmol), reserpine, theophylline, tricyclic antidepressants, and vasodilators. The effects of some drugs on catecholamine results may not be predictable.
Specimen Collection Requirements
Urine, 24-hour or random urine collection
5.0 mL aliquot from a well-mixed 24-hour or random collection. Record the total volume and collection time interval on the transport tube and test request form. Adequate refrigeration is the most important aspect of specimen preservation. Preservation can be enhanced by adjusting the pH to 2-3 by adding an acid such as 6 mol/L hydrochloric acid. Catecholamines are not stable above pH 7. The pH of such specimens must be adjusted by the addition of acid before transport. A pH less than 2 can cause assay interference.
Ambient: Unacceptable; Refrigerated: 1 week (unpreserved), 1 month (preserved); Frozen: 6 months (preserved)
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Monday, September 25, 2017 12:37:21 PM
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