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* DOXEPIN AND NORDOXEPIN, QUANTITATIVE, SERUM

Mnemonic

DOXEP

Synonym

Sinequan®

Includes

Doxepin and its metabolite, Nordoxepin

Specimen Collection Requirements

Patient Preparation

Collect specimens for therapeutic monitoring approximately 8-12 hours after last dose.

Collect

Serum or Plasma, one 7 mL red, 4 mL dark green (sodium heparin), or 4 mL lavender (EDTA) top tube. SST and PST tubes are NOT recommended.

Handling

Allow serum to clot completely at room temperature (minimum 30 minutes). Centrifuge and separate serum or plasma from cells ASAP.

Preferred Volume

3 mL Serum or Plasma

Minimum Volume

1 mL Serum or Plasma (Whole Blood 2 mL minimum draw)

Transport

Refrigerated (2-8°C)

Rejection Criteria

Gross hemolysis. Avoid gel separator tubes. If collected in such tubes remove ASAP.

Stability

Ambient (20-25°C): 1 week; Refrigerated (2-8°C): 2 weeks; Frozen (at or below -20°C): 6 months

Testing Information

Performed

7 days a week

Reported

24 hours

Method

Liquid Chromatography Tandem Mass Spectrometry

Reference Values

Toxic Levels

>500 ng/mL

Comments

Levels include the sum of Doxepin and N-desmethyl Doxepin (metabolite).

CPT Codes

80335

Last Updated: Wednesday, March 8, 2017 02:31:32 PM


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