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ERYTHROPOIETIN

Mnemonic

ERYTH

Synonym

EPO - ERYTH

Specimen Collection Requirements

Collect

Serum, one 5.0 mL gold (SST) or 7.0 mL red top tube

Handling

Allow serum tubes to clot completely at room temperature (minimum - SST: 30 minutes, red top tubes: 60 minutes). Centrifuge and separate serum from cells ASAP.

Preferred Volume

1.0 mL

Minimum Volume

0.4 mL Serum, (Whole Blood 1.3 mL minimum draw)

Transport

Refrigerated (2-8°C); if the specimen will be delayed more than 24 hours, send frozen (at or below -20°C)

Rejection Criteria

Grossly hemolyzed specimens or plasma

Stability

AFTER SEPARATION FROM CELLS: Room Temperature (20-25°C): 8 hours; Refrigerated (2-8°C): 24 hours; Frozen (at or below -20°C): 2 months

Testing Information

Performed

Mon, Wed, Fri

Reported

24-72 hours

Method

Chemiluminescent Immunoassay

Reference Values

Reference Values

4-27 mlU/mL

Normal serum concentrations of erythropoietin for 95% of individuals with normal hematocrits range from 4-27 mIU/mL.

As the hematocrit is lowered by iron deficiency, aplastic or hemolytic anemia, the concentration of erythropoietin increases as shown in the graph below. In the absence of anemia, elevated concentrations are seen in renal tumors, as a manifestation of renal transplant rejection, and in secondary polycythemia. Low values may be observed in hemochromatosis.

Decreased erythropoietin concentrations with an elevated hematocrit are observed in patients with polycythemia rubra vera, and with a decreased hematocrit in patients with HIV infection who are receiving AZT. Patients on AZT who have anemia and erythropoietin concentrations of less than or equal to 500 mIU/mL, may benefit from therapy with recombinant EPO (NEJM 322:1488-1493, 1990).

EXPECTED ERYTHROPOIETIN CONCENTRATIONS IN PATIENTS WITH UNCOMPLICATED ANEMIA

                    ERYTHROPOIETIN (mU/mL)

                100,000 -

     
                                     
                  10,000 -       .............
                                          .............
                                            .............
                                              .............
                    1,000 -                .............
                                                  .............
                                                    .............
                                                      .............
                        100 -                        .............
                                                          .............
                                                            .............
                          10 -                              .............
                                                                .............
                              ___________________________       
                                          10  20  30  40  50  60  70

                                              (HEMATOCRIT %)
(CONTRIBUTIONS TO NEPHROLOGY 1988:66:54-62)

CPT Codes

82668

Last Updated: Thursday, January 5, 2017 03:41:00 AM


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