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FISH PROBE: ALK

Mnemonic

ATTN FISH

Synonym

Anaplastic Large Cell Lymphoma - t(2;5)(p23;q35)

Guidelines

This probe detects translocations/variant rearrangements involving the ALK gene 2p23 region in non-small cell lung cancer (NSCLC) tissue specimens to aid in identifying those patients eligible for treatment with XALKORI® (crizotinib).

It is also useful for detecting translocations involving 2p23 in Anaplastic Large Cell Lymphoma (ALCL) where t(2;5) is the most frequent chromosome abnormality.

Specimen Collection Requirements

Handling

Testing Information

Performed

Mon - Fri

Reported

7 days

Method

Fluorescence In Situ Hybridization (FISH)

Reference Values

Reference Values

Professional interpretation provided by Cascade Pathology Services.

Comments

The partner chromosome of translocation can be determined by metaphase FISH, wherever applicable.

CPT Codes

88377 x 1

Last Updated: Tuesday, June 6, 2017 11:12:16 AM


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