3q27 - LAZ3 [Lymphoma Associated Zinc Finger on Chromosome 3] - Diffuse Large B-Cell Lymphomas [DLBCL]
This probe is designed to detect rearrangements involving BCL6 gene on chromosome 3 at 3q27 region. B cell non-Hodgkin Lymphomas (B-NHL) carry the greatest number of translocations involving the BCL6 gene locus.
Specimen Collection Requirements
Fluorescence In Situ Hybridization (FISH)
Professional interpretation provided by Cascade Pathology Services.
BCL6 gene is involved in various translocations involving: IGK, t(2;3)(p12;q27); MYC, t(3;8)(q27;q24.1); IGH, t(3;14)(q27;q32); IGL, t(3;22)(q27;q11) and others. The partner chromosome of translocation can be determined by metaphase FISH.
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