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FISH PROBE: BCL6

Mnemonic

ATTN FISH

Synonym

3q27 - LAZ3 [Lymphoma Associated Zinc Finger on Chromosome 3] - Diffuse Large B-Cell Lymphomas [DLBCL]

Guidelines

This probe is designed to detect rearrangements involving BCL6 gene on chromosome 3 at 3q27 region. B cell non-Hodgkin Lymphomas (B-NHL) carry the greatest number of translocations involving the BCL6 gene locus.

Specimen Collection Requirements

Handling

Testing Information

Performed

Mon - Fri

Reported

7 days

Method

Fluorescence In Situ Hybridization (FISH)

Reference Values

Reference Values

Professional interpretation provided by Cascade Pathology Services.

Comments

BCL6 gene is involved in various translocations involving: IGK, t(2;3)(p12;q27); MYC, t(3;8)(q27;q24.1); IGH, t(3;14)(q27;q32); IGL, t(3;22)(q27;q11) and others.  The partner chromosome of translocation can be determined by metaphase FISH.

CPT Codes

88377 x 1

Last Updated: Tuesday, June 6, 2017 11:12:17 AM


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