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FISH PROBE: BCR/ABL/ASS

Mnemonic

ADULT: ATTN FISH, PEDIATRIC: ATTN CYGEN

Synonym

t(9;22)(q34;q11.2) - Philadelphia Chromosome - t(9;22)

Guidelines

This dual fusion tricolor probe is designed to detect the classical t(9;22) and atypical rearrangements involving ABL1 and BCR genes on chromosome 9 and 22, respectively. This test is used for primary diagnosis or to monitor minimal residual diseases in CML patients.

Specimen Collection Requirements

Handling

Testing Information

Performed

Mon - Fri

Reported

7 days

Method

Fluorescence In Situ Hybridization (FISH)

Reference Values

Reference Values

Professional interpretation provided by Cascade Pathology Services.

Comments

Diagnosis of some chronic myeloproliferative diseases such as polycythemia vera, essential thromobocythemia require exclusion of BCR-ABL1 gene rearrangement.  In Acute Myeloid Leukemia/Acute Lymphoblastic Leukemia and in precursor T-lymphoblastic leukemia/lymphomas, BCR-ABL1 gene rearrangement and ABL1 gene amplification can be detected, respectively.  This probe is part of the Acute Myeloid Leukemia Panel (Adult), probes can be ordered individually.

CPT Codes

ADULT: 88377 x 1

Last Updated: Tuesday, June 6, 2017 11:12:17 AM


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