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FISH PROBE: FOXO1

Mnemonic

ADULT: ATTN FISH, PEDIATRIC: ATTN CYGEN

Synonym

(13q14) - FOXO1A - Alveolar Rhabdomyosarcoma - ARMS

Guidelines

This probe detects translocations/variant rearrangements involving FOXO1 gene on chromosome 13 at 13q14 region. Chromosomal translocations t(2;13)(q35;q14) and t(1;13)(p36;q14) have been found to be specific for ARMS. As the prognosis of ARMS is worse, it is important to accurately distinguish between ARMS and ERMS (embryonal rhabdomyosarcomas). The distinction maybe difficult based on morphology alone.

Specimen Collection Requirements

Handling

Testing Information

Performed

Mon - Fri

Reported

7 days

Method

Fluorescence In Situ Hybridization (FISH)

Reference Values

Reference Values

Professional interpretation provided by Cascade Pathology Services.

Comments

The partner chromosome of translocation can be determined by metaphase FISH, whenever applicable.

CPT Codes

ADULT: 88377 x 1

Last Updated: Tuesday, June 6, 2017 11:12:28 AM


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