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FISH PROBE: IGH/BCL2

Mnemonic

ATTN FISH

Synonym

t(14;18)(q32;q21) - IGH/BCL-2

Guidelines

This probe is designed to detect reciprocal translocation between chromosome 14 and 18, t(14;18)(q32;q21). This translocation is the most common translocation in human lymphoid malignancies and is characteristic of Follicular Lymphoma. It occurs in 70-90% of all follicular lymphomas and 10-30% of diffuse large cell lymphomas (DLBCL). This probe can differentiate between IGH-BCL2 and IGH-MALT1 rearrangements that are cytogenetically identical.

Specimen Collection Requirements

Handling

Testing Information

Performed

Mon - Fri

Reported

7 days

Method

Fluorescence In Situ Hybridization (FISH)

Reference Values

Reference Values

Professional interpretation provided by Cascade Pathology Services.

CPT Codes

88377 x 1

Last Updated: Tuesday, June 6, 2017 11:12:30 AM


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