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METHYLMALONIC ACID, QUANTITATIVE, BLOOD

Mnemonic

MMA S

Synonym

MMA - MMA S - MMA Quant Blood

Specimen Collection Requirements

Collect

Serum or EDTA Plasma, one 5.0 mL gold (SST), 7.0 mL red or 4.0 mL Lavender (EDTA) top tube

View image for Supply Item Number - 101235 or 101192 or 158386

Handling

Allow serum to clot completely at room temperature (minimum: SST - 30 minutes and red top tubes - 60 minutes). Separate serum or plasma from cells within 2 hours of collection.

Preferred Volume

2 mL Serum or EDTA plasma

Minimum Volume

1 mL Serum/Plasma (Whole Blood 3.0 mL minimum draw)

Transport

Refrigerated (2-8°C)

Rejection Criteria

Gross hemolysis, lithium heparin plasma

Stability

AFTER SEPARATION FROM CELLS: Ambient (18-26°C): 12 hours; Refrigerated (2-8°C): 7 days; Frozen (≤-20°C): 2 weeks

Testing Information

Performed

Sun, Tue, Thu

Reported

1-4 days

Method

Liquid Chromatography Tandem Mass Spectrometry

Reference Values

Reference Values

MMA (µmol/L)

Interpretation

0.00-0.40

Normal

0.41-0.99

Slight Elevation, consistent with mild vitamin B12 deficiency, renal insufficiency or intravascular volume

0.10-9.99

Moderate Elevation, Consistent with mild vitamin B12 deficiency

≥10.00

Massive Elevation, consistent with significant vitamin B12 deficiency or with inborn errors of metabolism

CPT Codes

83921

Last Updated: Friday, March 10, 2017 12:14:05 PM


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