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MULTIPLE SCLEROSIS SCREEN

Mnemonic

MS

Synonym

Immunoglobulin-G (IgG) Index - Oligoclonal Bands - IgG Index - IgG Synthesis Rate - MS - Isoelectric Focusing - IEF

Includes

CSF IgG Index (CSF IgG, CSF Albumin, Serum IgG, Serum Albumin), Oligoclonal Bands, IgG Synthesis Rate, CSF Total Protein

Guidelines

Note: Serum must be collected within 48 hours of CSF collection.

Specimen Collection Requirements

Collect

Serum and CSF, one 5.0 mL gold (SST) top tube or 7.0 mL red top tube AND 2.5 mL CSF in a sterile container

Handling

Allow serum to clot completely at room temperature (minimum: 30 minutes). Centrifuge and separate serum from red and white blood cells within one hour of collection.

Preferred Volume

2.0 mL Serum; 2.5 mL CSF

Minimum Volume

1.0 mL Serum; 2.0 mL CSF

Transport

Refrigerated (2-8°C)

Rejection Criteria

Hemolyzed specimens, plasma specimens and specimens collected outside the 48 hour window.

Stability

SERUM: Ambient (18-26°C): 8 hours; Refrigerated (2-8°C): 7 days; Frozen (at or below -20°C): 1 month.
CSF: Ambient (18-26°C): <1 hour; Refrigerated (2-8°C): 7 days; Frozen (at or below -20°C): 3 weeks if frozen within 24 hours of collection

Testing Information

Note

CSF with low total protein concentrations and/or low sample volume may need to be referred to an alternative laboratory for testing.

Performed

Monday and Thursday

Reported

4-6 days

Method

Isoelectric Focusing Electrophoresis, Nephelometry

Reference Values

Reference Values

Professional interpretation provided by Cascade Pathology Services.

CPT Codes

82040, 82784 (x2), 82042, 83916, 84157

Last Updated: Thursday, January 5, 2017 03:41:25 AM


Client Services: 503-413-1234