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OPIATES, QUANTITATIVE, SERUM

Mnemonic

OPIATE S

Synonym

Demerol - Dilaudid - MS Contin - Norco - OxyContin - Percocet - Percodan - Roxicet - Tylenol 3 - Vicodin

Includes

Morphine, Codeine, Meperidine, Oxycodone, Hydrocodone, Hydromorphone

Guidelines

This testing should only be ordered when a urine specimen is not available for testing. Urine is the preferred specimen for drugs of abuse testing.

Specimen Collection Requirements

Collect

Serum or Plasma, one 7.0 mL red, 4.0 mL dark green (sodium heparin) or 4.0 mL lavender (EDTA) top tube. SST and PST tubes are NOT recommended.

Handling

Allow serum to clot completely at room temperature (minimum: 30 minutes). Centrifuge and separate serum or plasma from cells ASAP.

Preferred Volume

3 mL Serum or Plasma

Minimum Volume

1 mL (Whole Blood 2.5 mL minimum draw)

Transport

Refrigerated (2-8°C)

Rejection Criteria

Serum that has been in contact with serum separator gel, whole blood, or grossly hemolyzed specimen.

Stability

Ambient(20-25°C): 24 hours; Refrigerated (2-8°C): 7 days

Testing Information

Performed

Wed, Fri

Reported

1-5 days

Method

Liquid Chromatography Tandem Mass Spectrometry

Reference Values

Reference Values

Not Detected
Morphine:             <10 ng/mL
Codeine:               <10 ng/mL
Meperidine :         <10 ng/mL
Hydromorphone: <10 ng/mL
Oxycodone:           <20 ng/mL
Hydrocodone:       <10 ng/mL

Comments

Note: This test detects free drug only. Glucuronide metabolites or other drug conjugates are not detected with this method.

CPT Codes

80361

Last Updated: Tuesday, August 1, 2017 08:15:38 AM


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