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THYROGLOBULIN, SERUM OR PLASMA WITH REFLEX TO LC-MS/MS OR CIA

Mnemonic

THYROGLO R

Includes

Thyroglobulin, Thyroglobulin antibody

Guidelines

Specimens negative for thyroglobulin antibodies (TgAb) are tested for thyroglobulin (Tg) by chemiluminescent immunoassay (CIA) using the Beckman Coulter Access® DxI method. Specimens with TgAb results above the upper reference limit are tested for Tg by high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results obtained with different test methods or kits cannot be used interchangeably. Tg results, regardless of concentration, should not be interpreted as absolute evidence for the presence or absence of papillary or follicular thyroid cancer. Tg testing is not recommended for use as a screening procedure to detect the presence of thyroid cancer in the general population.

Specimen Collection Requirements

Collect

Serum, one 6 mL gold (SST) top tube, also acceptable Plasma, green (sodium or lithium heparin) top tube.

Handling

Allow serum to clot, centrifuge, aliquot serum or plasma into plastic tube and freeze.

Preferred Volume

3.0 mL

Minimum Volume

1.5 mL

Transport

Frozen

Rejection Criteria

EDTA Plasma, any fluid other than noted above

Stability

AFTER SEPARATION FROM CELLS: Ambient: 8 hours; Refrigerated: 48 hours; Frozen: 6 months

Testing Information

Performed

7 days/week

Reported

2-6 days

Method

Quantitative Chemiluminescent Immunoassay/High Performance Chromatography-Tandem Mass Spectrometry

Referral Lab

ARUP (2006685 )

Reference Values

Reference Values

Interpretation provided.

CPT Codes

84432, 86800

Last Updated: Thursday, January 5, 2017 03:41:41 AM


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