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* TRICYCLIC ANTIDEPRESSANT PANEL, SERUM

Mnemonic

TCA PAN

Synonym

TCAD

Includes

Amitriptyline, Nortriptyline, Imipramine, Desipramine, Doxepin, Nordoxepin

Specimen Collection Requirements

Patient Preparation

Collect specimens for therapeutic monitoring approximately 8-12 hours after last dose.

Collect

Serum or Plasma, one 7 mL red, 4 mL dark green (sodium heparin), or 4 mL lavender (EDTA) top tube. SST and PST tubes are NOT recommended.

Handling

Allow serum to clot completely at room temperature (minimum: 30 minutes). Centrifuge and separate serum or plasma from cells ASAP.

Preferred Volume

3 mL Serum or Plasma

Minimum Volume

1 mL (Whole Blood 2.5 mL minimum draw)

Transport

Refrigerated (2-8°C)

Rejection Criteria

Gross hemolysis. Avoid gel separator tubes. If collected in such tubes remove ASAP.

Stability

Ambient (20-25°C): 1 week; Refrigerated (2-8°C): 2 weeks; Frozen (at or below -20°C): 6 months

Testing Information

Performed

7 days/week

Reported

24 hours

Method

Liquid Chromatography Tandem Mass Spectrometry

Reference Values

Therapeutic Range

Comments

Submit serum for this panel to confirm presumptive urine tricyclic antidepressant positive

CPT Codes

80337

Last Updated: Tuesday, March 14, 2017 04:42:40 PM


Client Services: 503-413-1234