eDocTalk article

Tech notes: Acetaminophen combo product changes

August 2013

Legacy Health hospitals are no longer stocking combination medications with more than 325 mg of acetaminophen per dosage unit. A dosage unit refers to one tablet or 15 mL.

This change is due to an FDA mandate that manufacturers limit the amount of acetaminophen in prescription drug products to 325 mg per dosage unit starting Jan. 1, 2014. This change is intended to reduce the risk of liver injury associated with acetaminophen. This does NOT apply to over-the-counter formulations of acetaminophen.

What does this mean to providers?

Providers will now find the following hydrocodone/acetaminophen products available for order:

HYDROCODONE-ACETAMINOPHEN 5-325 MG ORAL TAB

HYDROCODONE-ACETAMINOPHEN 7.5-325 MG ORAL TAB

HYDROCODONE-ACETAMINOPHEN 10-325 MG ORAL TAB

HYDROCODONE-ACETAMINOPHEN 7.5-325 MG/15 ML ORAL SOLN UD

HYDROCODONE-ACETAMINOPHEN 2.5-108 MG/5 ML ORAL SOLN UD

HYDROCODONE-ACETAMINOPHEN 5-325 MG ORAL TAB Take Home Pak

HYDROCODONE-ACETAMINOPHEN 2.5-108 MG/5 ML ORAL SOLN Take Home Pak

Other changes

Order sets and department preference lists will be updated to reflect these changes. If you have a saved personal version of an order set that contains a hydrocodone-acetaminophen product, you will see a pop up warning the first time you open the order set. You will see a warning similar to the screenshot below:

acetaminophen notation1

If a patient has a hydrocodone/acetaminophen-containing product with more than 325 mg of acetaminophen on their prior-to-admission medications list, you will see the following alternate therapy pop-up alert:

acetaminophen

More about the FDA ruling can be found at http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm239894.htm

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