Oral Antihistamine Medication for Itching

• Take an antihistamine like diphenhydramine (Benadryl) for widespread rashes that itch. The adult dosage of Benadryl is 25-50 mg by mouth 4 times daily.
  • Do not take antihistamine medications if you have prostate enlargement.
  • Antihistamines may cause sleepiness. Do not drink, drive or operate dangerous machinery while taking antihistamines.
  • An over-the-counter antihistamine that causes less sleepiness is loratadine (e.g., Alavert or Claritin).
  • Read the package instructions thoroughly on all medications that you take