BUPRENORPHINE & METABOLITES

Mnemonic

MISC

Guidelines

For medical purposes only; not valid for forensic use. The presence of metabolite(s) without parent drug may indicate use of parent drug during the prior week. The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive.

Specimen Collection Requirements

Collect

One plain red, lavender (EDTA), or pink (K2EDTA).

Handling

Remove serum/plasma from cells ASAP

Transport

2 mL serum or plasma at 2-8°C. (Min: 1 mL) Submit specimen in an Standard Transport Tube

Rejection Criteria

Specimens exposed to repeated freeze/thaw cycles. Separator tubes and plasma or whole blood from lt. blue tubes (sodium citrate).

Stability

After separation from cells: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years.

Testing Information

Performed

Sun-Sat

Method

Liquid Chromatography-Tandem Mass Spectrometry

Referral Lab

ARUP 2002742

Reference Values

Reference Values

Postive Cutoff: buprenorphine: 2 ng/mL norbuprenorphine: 2 ng/mL buprenorphine glucuronide: 5 ng/mL norbuprenorphine glucuronide:5 ng/mL

CPT Codes

83925

Last Updated: Thursday, January 5, 2017 03:42:01 AM