CHROMOSOMAL ANALYSIS CHORIONIC VILLUS

Mnemonic

MISC

Synonym

CVS - Karyotype - Karyotyping - Chromosomes - Chromosome Study - Cytogenetics

Guidelines

Direct preparation testing of the cytotrophoblasts will be performed for sex confirmation and to rule out maternal cell contamination when the sample is sufficient (10.0 mg or greater). Preliminary results will be released at the Director’s discretion. If the sample is insufficient for direct preparation testing and the final result shows apparently normal female, molecular studies to rule out maternal cell contamination are recommended.

Specimen Collection Requirements

Collect

Chorionic Villus aseptically placed into a sterile screw-top container covered with tissue culture transport media

Handling

Do not place specimen in formalin. Keep the specimen at ambient temperature and transport within 24 hours. Transport media can be obtained from the Cytogenetics Laboratory, by calling (503) 413-4613. Inappropriate handling may result in tissue culture failure.

Minimum Volume

An estimated weight of 10.0 mg or more

Transport

Room temperature within 24 hours of collection

Rejection Criteria

SPECIMENS SUBMITTED IN OR EXPOSED TO FORMALIN. Rejection is only at the discretion of the Cytogenetics Laboratory.

Stability

Ambient: 24 hours; Refrigerated: Suboptimal, call Cytogenetics Lab at (503) 413-4613

Testing Information

Note

Clinical information including the indication for study must accompany the specimen. This includes the gestational age, ultrasound findings, prenatal screening results, previous reproductive history and any known family history of birth defects. Requisition forms for cytogenetics studies are available upon request.

Performed

7 days/week

Reported

8-14 days

Method

Classical G-Band Chromosomal Analysis

Reference Values

Reference Values

Cytogenetics interpretation provided. A computer generated karyotype is also provided with each study.
Normal range:
46,XX, apparently normal female
46,XY, apparently normal male
If Genetic Counseling is needed, call (503) 413-5214.

Comments

For questions regarding the report, please call (503) 413-4613.

Last Updated: Thursday, January 5, 2017 03:42:03 AM