COCCIDIOIDES ANTIBODIES PANEL BY ID

Mnemonic

COCABGM

Synonym

Coccidioides Abs Panel, by CF, ID, ELISA

Guidelines

For Coccidioides, immunodiffusion (ID) measures IgM antibodies, while complement fixation (CF) measures both IgG and IgM. ELISA tests can be used to detect both coccidioidal IgG and IgM antibodies. While elevated single antibody titers may be diagnostic, paired samples are preferred. Acute and convalescent samples drawn at least 21 days apart, showing a fourfold or greater rise in titer, are diagnostic. Negative fungal serology does not rule out the possibility of current infection.

Specimen Collection Requirements

Collect

Serum, one 4.0 mL gold (SST) top tube

Handling

Separate serum from cells ASAP. Parallel testing is preferred. Convalescent specimens must be received within 30 days from receipt of the acute specimens. Please mark specimen plainly as Acute or Convalescent.

Preferred Volume

2.0 mL

Minimum Volume

0.6 mL

Transport

Refrigerated

Rejection Criteria

Other body fluids, severely lipemic, contaminated or hemolyzed specimens

Stability

AFTER SEPARATION FROM CELLS: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year, avoid repeated freeze/thaw cycles

Testing Information

Performed

Daily

Reported

3-6 days

Method

Complement Fixation/Immunodiffusion/Enzyme-Linked Immunosorbent Assay

Referral Lab

ARUP (50588)

Reference Values

Reference Values

Interpretation provided.

CPT Codes

86635 (X4)

Last Updated: Thursday, January 5, 2017 03:42:04 AM