IMIPRAMINE

Mnemonic

IMIP

Synonym

Tofranil®

Includes

Imipramine and its metabolite, Desipramine

Patient Preparation

Collect specimens for therapeutic monitoring approximately 8-12 hours after last dose.

Collect

Serum or Plasma, one 7 mL red, 4 mL dark green (sodium heparin), or 4 mL lavender (EDTA) top tube. SST and PST tubes are NOT recommended.

Handling

Allow serum to clot completely at room temperature (minimum 30 minutes). Centrifuge and separate serum or plasma from cells ASAP.

Preferred Volume

3 mL Serum or Plasma

Minimum Volume

1 mL Serum or Plasma (Whole blood 2 mL minimum draw)

Transport

Refrigerated (2-8°C)

Rejection Criteria

Gross hemolysis. Avoid gel separator tubes. If collected in such tubes remove ASAP.

Stability

Ambient (20-25°C): 1 week; Refrigerated (2-8°C): 2 weeks; Frozen (at or below -20°C): 6 months

Performed

7 days/week

Reported

24 hours

Method

Liquid Chromatography Tandem Mass Spectrometry

Therapeutic Range

Please see Therapeutic Drug Monitoring (TDM) Guidelines for Pediatrics and Adults

Toxic Levels

Please see Therapeutic Drug Monitoring (TDM) Guidelines for Pediatrics and Adults

CPT Codes

G0480

Last Updated: Thursday, January 5, 2017 03:42:16 AM