LEFLUNOMIDE METABOLITE (TERIFLUNOMIDE), SERUM
Therapeutic monitoring of patients actively taking leflunomide.
Assessment of elimination in patients requiring enhanced elimination of the drug.
Specimen Collection Requirements
Draw blood no sooner than 12 hours (trough value) after last dose.
Centrifuge within 2 hours of draw.
Serum separator tubes (SST), plasma, gross hemolysis or lipemia
Ambient: 28 days; Refrigerated: 28 days; Frozen: 28 days
High Turbulence Liquid Chromatography-Tandem Mass Spectrometry (HTLC-MS/MS)
Mayo Medical Laboratories (LEFLU)
Elimination: <0.020 mcg/mL
Leflunomide toxicity does not appear to correlate with teriflunomide concentrations, thus this assay is unlikely to aid in evaluation of potential adverse drug reactions.
Thursday, January 5, 2017 03:42:19 AM