LEFLUNOMIDE METABOLITE (TERIFLUNOMIDE), SERUM

Mnemonic

LEFLU

Synonym

Teriflunomide

Guidelines

Therapeutic monitoring of patients actively taking leflunomide.
Assessment of elimination in patients requiring enhanced elimination of the drug.

Specimen Collection Requirements

Patient Preparation

Draw blood no sooner than 12 hours (trough value) after last dose.

Collect

Serum, one red top tube

Handling

Centrifuge within 2 hours of draw.

Preferred Volume

1.0 mL

Minimum Volume

0.3 mL

Transport

Refrigerated

Rejection Criteria

Serum separator tubes (SST), plasma, gross hemolysis or lipemia

Stability

Ambient: 28 days; Refrigerated: 28 days; Frozen: 28 days

Testing Information

Performed

Mon, Wed, Fri

Reported

5-7 days

Method

High Turbulence Liquid Chromatography-Tandem Mass Spectrometry (HTLC-MS/MS)

Referral Lab

Mayo Medical Laboratories (LEFLU)

Reference Values

Therapeutic Range

>40 mcg/mL

Elimination: <0.020 mcg/mL

Comments

Leflunomide toxicity does not appear to correlate with teriflunomide concentrations, thus this assay is unlikely to aid in evaluation of potential adverse drug reactions.

CPT Codes

80299

Last Updated: Thursday, January 5, 2017 03:42:19 AM