TRICYCLIC ANTIDEPRESSANT PANEL, SERUM

Mnemonic

MISC

Synonym

TCAD

Includes

Amitriptyline, Nortriptyline, Imipramine, Desipramine, Doxepin, Nordoxepin

Specimen Collection Requirements

Patient Preparation

Collect specimens for therapeutic monitoring approximately 8-12 hours after last dose.

Collect

Serum or Plasma, one 7 mL red, 4 mL dark green (sodium heparin), or 4 mL lavender (EDTA) top tube. SST and PST tubes are NOT recommended.

Handling

Allow serum to clot completely at room temperature (minimum: 30 minutes). Centrifuge and separate serum or plasma from cells ASAP.

Preferred Volume

3 mL Serum or Plasma

Minimum Volume

1 mL (Whole Blood 2.5 mL minimum draw)

Transport

Refrigerated (2-8°C)

Rejection Criteria

Gross hemolysis. Avoid gel separator tubes. If collected in such tubes remove ASAP.

Stability

Ambient (20-25°C): 1 week; Refrigerated (2-8°C): 2 weeks; Frozen (at or below -20°C): 6 months

Testing Information

Performed

7 days/week

Reported

24 hours

Method

Liquid Chromatography Tandem Mass Spectrometry

Reference Values

Therapeutic Range

Comments

Submit serum for this panel to confirm presumptive urine tricyclic antidepressant positive

CPT Codes

80337;G0480

Last Updated: Thursday, January 5, 2017 03:42:32 AM