VARICELLA-ZOSTER VIRUS ANTIBODIES, IGG & IGM

Mnemonic

MISC

Specimen Collection Requirements

Collect

Serum separator tube

Handling

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to a Standard Transport Tube. Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as "acute" or "convalescent."

Preferred Volume

0.25 mL

Minimum Volume

1.0 mL

Transport

Refrigerated.

Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Testing Information

Performed

Sun-Sat

Method

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Reference Values

Reference Values

Varicella-Zoster Virus Antibody, IgG Varicella-Zoster Virus Antibody, IgM
0.89 IV or less: Negative - No significant level of detectable varicella-zoster IgG antibody. 0.90-1.09 IV: Equivocal - Repeat testing in 10-14 days may be helpful. 1.10 IV or greater: Positive - IgG antibody to varicella-zoster detected, which may indicate a current or past varicella-zoster infection. Positive IgG antibody levels in the absence of current clinical symptoms may indicate immunity (98% correlation with IFA). 0.90 ISR or less: Negative - No significant level of detectable varicella-zoster virus IgM antibody. 0.91-1.09 ISR: Equivocal - Repeat testing in 10-14 days may be helpful. 1.10 ISR or greater: Positive - Significant level of detectable varicella-zoster virus IgM antibody. Indicative of current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection or immunization

CPT Codes

86787 VZ IgG; 86787 VZ IgM

Last Updated: Thursday, January 5, 2017 03:42:33 AM