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* ANTITHROMBIN ACTIVITY

Mnemonic

AT

Synonym

Heparin Co-Factor - AT III - AT III Functional Activity

Guidelines

Measures activity of AT present in plasma. Values may decrease in inherited and acquired deficiencies and liver disease. Heparin and Coumadin do not interfere with the assay but may alter physiologic values.

Specimen Collection Requirements

Collect

Whole Blood light blue top tube (3.2% Buffered Sodium Citrate)

Handling

See Coagulation Specimen Collection Guidelines. Due to short stability, whole blood specimen tubes must reach the testing department within 4 hours, otherwise submit frozen plasma aliquots. NOTE: Frost-free refrigerator freezers are not acceptable for frozen sample storage. If proper storage is unavailable at the collection site, freeze/store aliquots on dry ice. Alternatively, send the patient to the nearest Legacy Hospital Outpatient Lab for sample collection/processing.

If submitting whole blood, transport at ambient temperature (15-25°C) in original unopened tube. If submitting frozen plasma aliquots, specimens must remain frozen (-20°C) during transport.

Preferred Volume

One 2.7 mL whole blood or two 1.0 mL frozen plasma aliquots

Minimum Volume

One 1.8 mL whole blood or one 1.0 mL frozen plasma aliquot

Transport

Whole Blood: Ambient (15-25°C)

Plasma: Frozen (-20°C), aliquots must remain frozen during storage and transport

Rejection Criteria

Whole Blood Refrigerated (2-8°C), clotted samples, samples collected in containers other than 3.2% Buffered Sodium Citrate, tubes filled less than 90%, samples from patients with a Hematocrit greater than 55%, hemolyzed samples due to ex-vivo causes (i.e., difficult draw, poor sample draw), whole blood samples that were frozen before processing

Stability

WHOLE BLOOD: Ambient: 4 hours

PLASMA: Ambient: 4 hours; Frozen: (-20°C): 2 weeks, (-70°C): 6 months

Testing Information

Performed

STAT and Inpatient: Legacy Emanuel Lab 24/7
Routine Orders and Outreach: Legacy Central Lab, Daily, Mon-Fri (0800-1530)

Reported

STAT: 2 hours
Routine: 48 hours

Method

Chromogenic

Reference Values

Reference Values

Varies, see report.

CPT Codes

85300

Last Updated: Thursday, March 14, 2019 12:50:23 PM


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