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Cardiolipin Antibodies, IgG, IgM, IGA

Mnemonic

CARD GMA

Synonym

ACA - aCL Antibody - aCL IgA - aCL IgG - aCL IgM - Anticardiolipin Antibodies - Cardiolipin - Anti-Cardiolipin Antibody

Includes

Cardiolipin Antibodies, IgG, IgM, IGA

Guidelines

Anti-cardiolipin antibodies have been strongly associated with venous and arterial thrombosis. In patients with SLE, a statistically significant association exists between the presence of anti-cardiolipin antibodies and a history of thrombosis, neurological disorders, fetal loss and thrombocytopenia.

Specimen Collection Requirements

Collect

Serum, one 5.0 mL gold (SST) or 7.0 mL red top tube

Supply Item Number – 101235 or 101192

Handling

Allow serum to clot completely at room temperature. Separate serum from cells ASAP.

Preferred Volume

1.0 mL Serum

Minimum Volume

0.5 mL Serum (whole blood 1.2 mL minimum draw)

Transport

Frozen

Rejection Criteria

Plasma. Microbially contaminated, heat treated, specimens containing visible particulates, grossly hemolyzed, and grossly lipemic specimens.

Stability

AFTER SEPARATION FROM CELLS: Ambient (18-26°C): 8 hours; Refrigerated (2-8°C): 48 hours; Frozen (at or below -20°C): 2 months

Testing Information

Performed

Tuesday, Friday

Reported

2-5 days

Method

Chemiluminescent Immunoassay

Reference Values

Reference Values

Cardiolipin IgA Antibody:

 

0 – 19 CU    Negative

  >=20 CU    Positive

 

Cardiolipin IgG Antibody:

 

  0 – 19 CU    Negative

20 – 94 CU    Low Positive

   >= 95 CU    Moderately to High Positive

 

Cardiolipin IgM Antibody:

 

  0 – 19 CU    Negative

20 – 30 CU    Low Positive

   >= 31 CU    Moderately to High Positive

 

Presence of antiphospholipid antibody syndrome should be considered if cardiolipin IgG and/or IgM antibody is present at moderate or above level on two or more occasions, at least 12 weeks apart. (Miyakis et al. (2005) Journal of Thrombosis and Haemostasis 4, 295-306.) Laboratory results must be correlated with clinical picture of the patient before making the diagnosis.


CPT Codes

86147 (x3)

Last Updated: Wednesday, January 27, 2021 01:01:02 AM


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