Catecholamines, Urine Fractionated Free
Adrenaline - Dopamine - Epinephrine - Noradrenaline - Norepinephrine
Specimen Collection Requirements
Drugs and medications may affect results and should be discontinued for at least 72 hours prior to specimen collection, if possible. Medications which may physiologically interfere with catecholamines and metabolites include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, carbidopa-levodopa (Sinemet®), clonidine, dexamethasone, diuretics (in doses sufficient to deplete sodium), ethanol, isoproterenol, methyldopa (Aldomet®), MAO inhibitors, nicotine, nose drops, propafenone (Rythmol), reserpine, theophylline, tricyclic antidepressants, and vasodilators. The effects of some drugs on catecholamine results may not be predictable.
Urine, 24-hour or random urine collection
5.0 mL aliquot from a well-mixed 24-hour or random collection. Record the total volume and collection time interval on the transport tube and test request form. Adequate refrigeration is the most important aspect of specimen preservation. Preservation can be enhanced by adjusting the pH to 2-3 by adding an acid such as 6 mol/L hydrochloric acid. Catecholamines are not stable above pH 7. The pH of such specimens must be adjusted by the addition of acid before transport. A pH less than 2 can cause assay interference.
Specimens preserved with boric acid or acetic acid. Specimens with pH greater than 7.
Unpreserved: Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Undefined
Preserved: Ambient: Unacceptable; Refrigerated: 1 month; Frozen: 6 months
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Friday, November 15, 2019 06:21:11 PM
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