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Chromosomal Analysis Products of Conception or Stillbirth

Synonym

Karyotype - Karyotyping - Chromosomes - Chromosome Study - Cytogenetics

Specimen Collection Requirements

Collect

Biopsy of viable tissue that is fetal in addition to extraembryonic in origin, obtained aseptically

Handling

Do not send the entire products of conception (POC) or stillbirth. If necessary, send POC to Pathology for dissection first.
Sending tissue from two sites is recommended. Chorionic villi or placenta are optimal due to increased viability in culture. Place in a screw-top container and cover with sterile Hanks BSS, normal saline or RPMI transport media. Do NOT place into formalin. Indicate the site of the tissue, i.e., heart, lung, thymus. Keep specimen at ambient temperature and transport within 24 hours.

Minimum Volume

Approximatey 1.0 cm3 viable tissue that is fetal in origin

Transport

Room temperature within 24 hours of collection

Rejection Criteria

SPECIMENS SUBMITTED IN OR EXPOSED TO FORMALIN. Rejection is only at the discretion of the Cytogenetics Laboratory.

Stability

Ambient: 24 hours; Refrigerated: Suboptimal, call Cytogenetics Lab at (503) 413-4613

Testing Information

Note

Clinical information including the indication for study must accompany the specimen. This includes a detailed list of congenital abnormalities noted prenatally or at the time of the demise, reproductive history with known carrier status for genetic conditions and gestational age of the fetal demise. Requisition forms for cytogenetics studies are available upon request.

Performed

7 days/week

Reported

3-4 weeks

Method

Classical G-Band Chromosomal Analysis

Reference Values

Reference Values

Cytogenetics interpretation provided. A computer generated karyotype is also provided with each study.
Normal range:
46,XX, apparently normal female
46,XY, apparently normal male
If Genetic Counseling is needed, call (503) 413-5214.

Comments

For questions regarding the report, please call (503) 413-4613.

Last Updated: Tuesday, January 21, 2020 01:14:41 AM


Client Services: 503-413-1234