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COBALT, SERUM

Mnemonic

COBALT S

Guidelines

Serum cobalt levels can be used in the assessment of occupational exposure or toxic ingestion and is the preferred specimen type for evaluating metal ion release from metal-on-metal joint arthroplasty. Serum cobalt levels may be increased in asymptomatic patients with metal-on-metal prosthetics and should be considered in the context of the overall clinical scenario. Symptoms associated with cobalt toxicity vary based on route of exposure, and may include cardiomyopathy, allergic dermatitis, pulmonary fibrosis, cough and dyspnea.

Specimen Collection Requirements

Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician).

Collect

Serum or Plasma, one royal blue (no additive) or royal blue (EDTA) top tube

Handling

Centrifuge; do not allow serum to remain on cells. Transfer 2.0 mL serum or plasma into a trace element metal-free transfer tube (view image).

Documentation verifying our supplied transfer tubes are trace element metal-free.

Preferred Volume

2.0 mL

Minimum Volume

0.5 mL (Whole Blood 1.2 mL minimum draw)

Transport

Room temperature

Rejection Criteria

Separator tubes, specimens that are not separated from red cells or clot within 6 hours

Stability

If the specimen is drawn and stored in the appropriate container, the trace element values do not change with time.

Testing Information

Performed

Daily

Reported

2-6 days

Method

Quantitative Inductively Coupled Plasma-Mass Spectrometry

Referral Lab

ARUP (25037)

Reference Values

Reference Values

Less than or equal to 1.0 µg/L

CPT Codes

83018

Last Updated: Thursday, March 14, 2019 12:50:31 PM


Client Services: 503-413-1234