Serum cobalt levels can be used in the assessment of occupational exposure or toxic ingestion and is the preferred specimen type for evaluating metal ion release from metal-on-metal joint arthroplasty. Serum cobalt levels may be increased in asymptomatic patients with metal-on-metal prosthetics and should be considered in the context of the overall clinical scenario. Symptoms associated with cobalt toxicity vary based on route of exposure, and may include cardiomyopathy, allergic dermatitis, pulmonary fibrosis, cough and dyspnea.
Specimen Collection Requirements
Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician).
Serum or Plasma, one royal blue (no additive) or royal blue (EDTA) top tube
0.5 mL (Whole Blood 1.2 mL minimum draw)
Separator tubes, specimens that are not separated from red cells or clot within 6 hours
If the specimen is drawn and stored in the appropriate container, the trace element values do not change with time.
Quantitative Inductively Coupled Plasma-Mass Spectrometry
Less than or equal to 1.0 µg/L
Thursday, March 14, 2019 12:50:31 PM
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