t(14;18)(q32;q21) - IGH/BCL-2
This probe is designed to detect reciprocal translocation between chromosome 14 and 18, t(14;18)(q32;q21). This translocation is the most common translocation in human lymphoid malignancies and is characteristic of Follicular Lymphoma. It occurs in 70-90% of all follicular lymphomas and 10-30% of diffuse large cell lymphomas (DLBCL). This probe can differentiate between IGH-BCL2 and IGH-MALT1 rearrangements that are cytogenetically identical.
Specimen Collection Requirements
Fluorescence In Situ Hybridization (FISH)
Professional interpretation provided by Cascade Pathology Services.
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