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FISH PROBE: TP53/ATM/MYB

Mnemonic

ATTN FISH

Synonym

(17p13.1)/(11q22.3)/(6q23) - P53/ataxia telangiectasia mutated/MYBC

Guidelines

This tricolor probe set detects deletions of: TP53 gene on chromosome 17 at 17p13 region, ATM gene on chromosome 11 at 11q22-23 region and MYB on chromosome 6 at q23 region. These deletions are associated with B-cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Deletions of 17p and 11q are associated with an adverse clinical outcome, with poor and short survival. Deletions of 6q are known to be the fourth most common chromosome aberrations in B-CLL.

Specimen Collection Requirements

Handling

Testing Information

Performed

Mon - Fri

Reported

7 days

Method

Fluorescence In Situ Hybridization (FISH)

Reference Values

Reference Values

Professional interpretation provided by Cascade Pathology Services.

Comments

This probe is part of the Chronic Lymphocytic Leukemia Panel, probes can be ordered individually.

CPT Codes

88377 x 1

Last Updated: Thursday, March 14, 2019 12:50:42 PM


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