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Herpes Simplex Virus Type 2 Glycoprotein G-Specific, IgG

Mnemonic

HSV2 IGG

Synonym

Herpes Simplex glycoprotein G - HerpeSelect - HSV 2 typing - HSV Type 2 IgG Specific Ab - HSV typing - HSV-2 - HSV 2 type specific glycoprotein G IgG

Guidelines

Detects type specific antibody against HSV2. May indicate primary, recurrent or past infection/exposure. Because almost all HSV2 infections are sexually acquired, type-specific HSV2 antibody indicates anogenital infection (per CDC).

Specimen Collection Requirements

Collect

Serum, one 5.0 mL gold (SST) or 7.0 mL red top tube

Handling

Allow serum to clot completely at room temperature (minimum – SST: 30 minutes, red top tubes: 60 minutes). Centrifuge and separate serum from cells ASAP.

Preferred Volume

0.5 mL Serum

Minimum Volume

0.25 mL Serum (0.75 mL minimum whole blood draw)

Transport

Refrigerated (2-8°C)

Rejection Criteria

Grossly hemolyzed, icteric or lipemic specimens; contaminated specimens; heat inactivated specimens; plasma.

Stability

AFTER SEPARATION FROM CELLS:  Room temperature (18-26°C): Unacceptable; Refrigerated (2-8°C): 7 days; Frozen (≤ -10°C): 30 days (not more than 5 freeze/thaw cycles).

Testing Information

Performed

Mon-Fri

Reported

24-72 hours

Method

Chemiluminescent Immunoassay

Reference Values

Reference Values

<= 0.89 Index          Negative for IgG antibody to HSV type 2 glycoprotein G.  Repeat testing in 4-6 weeks may be helpful.

0.90 – 1.09 Index    Equivocal for IgG antibody to HSV type 2 glycoprotein G.  Repeat testing in 4-6 weeks may be helpful.

>= 1.10 Index          Positive for IgG antibody to HSV type 2 glycoprotein G.

CPT Codes

86696

Last Updated: Wednesday, January 27, 2021 02:18:38 AM


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