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Homocysteine

Mnemonic

HOMOCY QNT

Synonym

HCY

Guidelines

Since specimen handling is critical to accuracy of test results, do not order on previously collected specimens (NO “ADD-ONS”).

Please see: Homocysteine Collection Requirements Revised

Specimen Collection Requirements

Collect

Preferred: Plasma, 4.0 mL Lavender (EDTA) top tube

Also acceptable: Serum or Plasma, one 5.0 mL gold (SST), 7.0 mL red or 3.0 mL mint green (lithium heparin, PST) top tube

NOTE: Serum concentrations have been observed to be up to 10% higher than plasma due to cells producing more homocysteine during the clotting process.

Handling

PLASMA: Preferred handling - Centrifuge and remove plasma from cells within 15 minutes of collection. Transfer to a separate aliquot tube.  Immediately, refrigerate plasma for Plasma Samples transport. Alternative handling - If immediate centrifugation is not possible, place whole blood specimens on ICE after collection. Centrifuge and remove plasma from cells within 6 hours of collection (if on ice). Transfer to a separate aliquot tube. Immediately, refrigerate plasma for transport.

SERUM: Required handling - Place whole blood specimens on ICE after collection. Allow serum to clot completely on ICE (minimum: 30 minutes). Centrifuge and remove serum from cells within 6 hours of collection. Transfer to a separate labeled aliquot tube. Immediately, refrigerate serum for transport.

 

IMPORTANT: Do not store serum or plasma at room temperature prior to centrifugation. Specimens not placed on ice immediately (or processed within 15 minutes) may exhibit a 10-20% increase in homocysteine concentration.

Preferred Volume

1.0 mL Serum/Plasma

Minimum Volume

0.25 mL Serum/Plasma (0.60 mL minimum whole blood draw)

Transport

Critical Refrigerated (2 -8°C)

Rejection Criteria

Marked lipemic, icteric and hemolyzed specimens, specimens that have undergone more than one freeze-thaw. No Add-On Requests.

Stability

AFTER REMOVAL FROM CELLS: Room Temperature (18-26°C): 3 hours; Refrigerated (2-8°C): 2 weeks; Frozen (≤ -20°C): 8 months (avoid more than one freeze/thaw)

Testing Information

Note

It is not recommended to use patient results from serum, heparinized plasma, and EDTA plasma interchangeably.

Performed

Mon - Fri

Reported

1-4 days

Method

Enzymatic

Reference Values

Reference Values

Age

Male and Females

0 - 2 months

Not established

2 months – 11 years

3.3 – 8.3 µmol/L

11 – 16 years

4.7 – 10.3 µmol/L

16 - 19 years

4.7 – 11.3 µmol/L

≥ 19 years

5.0 – 14.0 µmol/L

CPT Codes

83090

Last Updated: Saturday, January 30, 2021 01:52:18 AM


Client Services: 503-413-1234