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Myasthenia Gravis Evaluation Adult MAYO

Mnemonic

MGA1

Synonym

Myasthenia Gravis (MG) Evaluation, Adult, Serum

Includes

MG Adult Interpretation, S; ACh Receptor (Muscle) Binding Ab, ACh Receptor (Muscle) Modulating Ab, Striational (Striated Muscle) Ab, S

Reflex tests:

GAD65 Ab Assay, S; CRMP-5-IgG Western Blot, S; AChR Ganglionic Neuronal Ab, S; Neuronal (V-G) K+ Channel Ab, S

Testing algorithm:

If acetylcholine receptor (AChR) modulating antibodies are > or =90% and striational antibodies are > or =1:120, then AChR ganglionic neuronal autoantibody, glutamic acid decarboxylase autoantibody, neuronal voltage-gated potassium channel autoantibody, and CRMP-5-IgG Western blot will be performed at an additional charge.

Guidelines

This test is useful for the:

 

  • Initial evaluation of patients aged 20 or older with symptoms and signs of acquired myasthenia gravis (MG)

     

  • Bone marrow transplant recipients with suspected graft-versus-host disease, particularly if weakness has appeared

     

  • Confirming that a recently acquired neurological disorder has an autoimmune basis (eg, MG)

     

  • Providing a quantitative baseline for future comparisons in monitoring a patient's clinical course and the response to immunomodulatory treatment

 

  • Raising likelihood of neoplasia

Specimen Collection Requirements

Patient Preparation

Patient should have no general anesthetic or muscle-relaxant drugs in the previous 24 hours.

Collect

Serum, one 5.0 mL gold (SST) or 7.0 mL red top tube.

Supply Item Number - 101235 or 101192

Handling

Separate serum from cells ASAP or within 2 hours of collection. Transfer serum to an aliquot tube.

Preferred Volume

3 mL

Minimum Volume

2 mL

Transport

Refrigerated

Rejection Criteria

Gross hemolyzed, lipemic or icteric specimens. Plasma specimens.

Stability

AFTER SEPARATION FROM CELLS: Room Temperature (18-26°C): 72 hours; Refrigerated (2-8°C): 28 days; Frozen (at or below -20°C): 28 days

Testing Information

Performed

Sunday - Saturday

Reported

8 days

Method

ARBI, ARMO, GANG, VGKC: Radioimmunoassay (RIA)

STR: Enzyme Immunoassay (EIA)

Referral Lab

Mayo Medical Laboratories ((MGA1)

Reference Values

Reference Values

Interpretation provided

CPT Codes

83519 x 2, 83520, 83519 x 2 (if appropriate), 84182 (if appropriate), 86341 (if appropriate)

Last Updated: Monday, August 10, 2020 10:06:07 PM


Client Services: 503-413-1234