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Nonalcoholic Steatohepatitis (NASH)

Mnemonic

NSFIB

Synonym

NASH FibroTest

Includes

This test is a patented test algorithm developed by BioPredictive. It combines 10 standard biomarkers: gamma-glutamyltransferase (GGT), total bilirubin, alpha-2-macroglobulin, apolipoprotein A1, haptoglobin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol, triglycerides, and fasting glucose. These markers are weighted depending on the patient's age and gender.

Guidelines

This test is useful for: Diagnosis and the follow-up of liver fibrosis, steatosis and inflammation. Estimating hepatic fibrosis. Assessing inflammation for metabolic diseases. It is interpretable for assessing severity of nonalcoholic steatohepatitis (NASH) in patients with nonalcoholic fatty liver disease with steatosis (NAFLD). Assessing steatosis or fatty liver. Reassuring patients with steatosis only, without fibrosis. Managing patients with severe injuries such as advanced fibrosis and NASH.

Specimen Collection Requirements

Patient Preparation

Fasting for 12 hours or more is required.

Collect

Both Serum and Plasma are required for this test. Serum, one 5.0 mL gold (SST). Plasma, one 4.0 mL gray (sodium fluoride/potassium oxalate)

Handling

Serum specimen must be protected from light within 4 hours of collection. Specimen should be centrifuged within two hours of collection.

Preferred Volume

Serum: 4 mL Plasma: 1 mL

Minimum Volume

Serum: 2 mL  Plasma: 0.25 mL

Transport

Refrigerated

Rejection Criteria

Gross hemolysis, lipemia, and icterus. Specimens not protected from light. Specimens collected from patients <14 years of age.

Stability

Serum: Refrigerated- 7 days, Frozen- 14 days, Ambient- 24 hours

Plasma: Refrigerated- 7 days, Frozen- 14 days, Ambient- 7 days

Testing Information

Note

Indicate Serum or Plasma on each aliquot

Performed

Monday-Saturday

Reported

3-5 days

Method

Varies by analyte. See referral lab website for specific methodology

Referral Lab

Mayo (NSFIB)

Reference Values

Reference Values

Interpretation provided

CPT Codes

0003M

Last Updated: Wednesday, October 23, 2019 02:32:58 AM


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