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Paraneoplastic Autoantibody Evaluation MAYO

Mnemonic

PNPABE

Synonym

Paraneoplastic AutoAb Eval MAYO - PAVAL

Includes

ACh receptor (muscle) binding antibody
AChR ganglionic neuronal antibod
Neuronal VGKC autoantibody
N-type calcium channel antibody
P/Q-type calcium channel antibody
Striational (striated muscle) antibodies
AGNA-1
Amphiphysin
ANNA-1
ANNA-2
ANNA-3
CRMP-5-IgG
PCA-1
PCA-2
PCA-Tr
 

Guidelines

This test is useful for the

Serological evaluation of patients who present with a subacute neurological disorder of undetermined etiology, especially those with known risk factors for cancer. 

Directing a focused search for cancer. 

Investigating neurological symptoms that appear in the course of, or after, cancer therapy, and are not explainable by metastasis.

Differentiating autoimmune neuropathies from neurotoxic effects of chemotherapy.

Monitoring the immune response of seropositive patients in the course of cancer therapy.

Detecting early evidence of cancer recurrence in previously seropositive patients.

 

 

Specimen Collection Requirements

Collect

Serum, two 5.0 mL gold (SST) top tubes

Handling

Separate serum from cells ASAP or within 2 hours of collection.Transfer serum to an aliquot tube.

Preferred Volume

4.0 mL Serum

Minimum Volume

2.0 mL Serum

Transport

Refrigerated

Rejection Criteria

Hemolyzed, lipemic, or icteric specimens

Stability

Ambient: 72 hours; Refrigerated: 28 days; Frozen: 28 days  

Testing Information

Performed

Mon - Fri

Reported

Due to reagent shortage, the test is delayed beyond 10 days of reporting. No TAT has been provided.

Method

Immunofluorescence and Radioimmunoprecipitation

Referral Lab

Mayo Medical Laboratories (PAVAL)

Reference Values

Reference Values

Interpretation provided

CPT Codes

83519 (X5), 83520, 86255(X9)

Last Updated: Tuesday, August 11, 2020 02:32:29 AM


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