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* TRICYCLIC ANTIDEPRESSANTS SCREEN, URINE

Mnemonic

U M TCA

Synonym

Antidepressant Screen, Urine

Includes

Includes these antidepressants: Amitriptyline / Nortriptyline, Doxepin / Nordoxepin, Imipramine / Desipramine, Clomipramine, Trimipramine, and Protriptyline.

Cyclobenzaprine is also included. Cyclobenzaprine, a muscle relaxant, is chemically a tricyclic. However, it is not an antidepressant and it does not have the same cardiac toxicity as the Tricyclic Antidepressants. Patients with Cyclobenzaprine exposure will test Presumptive Detected for Tricyclics.

Guidelines

This is a presumptive screening test.  If the screening result is PRESUMPTIVE DETECTED and diagnosing whether or not a Tricyclic Antidepressant has been ingested it is highly recommended that TRICYCLIC ANTIDEPRESSANT PANEL, SERUM (TCA PAN) be ordered.

Specimen Collection Requirements

Collect

Collect urine in a sterile container.

Handling

Refrigerated (2-8°C)

Preferred Volume

10 mL

Minimum Volume

5 mL

Transport

Refrigerated (2-8°C)

Rejection Criteria

If sufficient specimen is not received, the test may not be performed.

Testing Information

Performed

7 days/week

Reported

24 hours

Method

Enzyme Immunoassay

Reference Values

Reference Values

None Detected (< 300 ng/mL Nortriptyline Equivalents)

Comments

If detected, a serum tricyclic panel is recommended.

CPT Codes

80307

Last Updated: Thursday, March 14, 2019 12:51:13 PM


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