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Valproic Acid, Free and Total

Mnemonic

VATF

Synonym

Depakane® - Depakote - Valproate - VALP TF

Includes

Total and Free Valproic Acid, % Bound

Guidelines

For information on when to collect specimen, please refer to Therapeutic Drug Monitoring (TDM) Guidelines for Pediatrics and Adults.

Specimen Collection Requirements

Collect

Serum or Plasma, one 5.0 mL gold (SST), 7.0 mL red or 3.0 mL mint green (lithium heparin, PST) top tube

Handling

Allow serum to clot completely at room temperature (minimum: 30 minutes). Centrifuge and separate serum and plasma from cells ASAP.

Preferred Volume

2.0 mL Serum/Plasma

Minimum Volume

1.5 mL Serum/Plasma (3.0 mL minimum whole blood draw)

Transport

Refrigerated (2-8°C)

Rejection Criteria

Grossly hemolyzed specimens

Stability

AFTER SEPARATION FROM CELLS: Room Temperature (18-26°C): 2 days; Refrigerated (2-8°C): 7 days; Frozen (≤ -20°C): 1 year

Testing Information

Performed

7 days/week

Reported

24 hours

Method

EMIT

Reference Values

Therapeutic Range

For Therapeutic Ranges, please refer to Therapeutic Drug Monitoring (TDM) Guidelines for Pediatrics and Adults

Toxic Levels

For Toxic Values, please refer to Therapeutic Drug Monitoring (TDM) Guidelines for Pediatrics and Adults

CPT Codes

Valproic Acid, Free: 80165, Valproic Acid, Total:80164

Last Updated: Tuesday, January 26, 2021 12:47:43 AM

Client Services: 503-413-1234