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Zika Virus IgM Antibody Capture (MAC), by ELISA

Mnemonic

ZIKA MAC

Synonym

Zika IgM Ab capture ARUP

Guidelines

Use for patients whose symptoms began, or whose documented exposure occurred, at least 14 days prior to testing. Should also be used as follow-up for patients with negative serum and urine results from molecular testing performed less than 14 days after symptom onset.

Please complete the following form: Patient History for Zika Virus Testing 

Specimen Collection Requirements

Collect

Serum

Handling

Separate from cells ASAP or within 2 hours of collection.

Preferred Volume

2.0 mL 

Minimum Volume

1.0 mL

Transport

Refrigerated 

Rejection Criteria

Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens. 

Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 

Testing Information

Note

Patient History for Zika Virus Testing must be submitted with specimen. 

Performed

Mon, Wed, Fri

Reported

2-7 days

Method

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Referral Lab

ARUP 2013942

Reference Values

Comments

The ZIKV Detect IgM Capture ELISA assay is intended for in vitro diagnostic use under FDA Emergency Use Authorization (EUA). This test has not been FDA cleared or approved. In compliance with this authorization, please visit https://aruplab.com/zika for more information and to access the applicable information sheets.

The possibility of false-positive or false-negative results must be considered. RT-PCR testing on both a serum and urine specimen is recommended by the Centers for Disease Control and Prevention (CDC) to rule out false-negative IgM results in patients experiencing symptoms for less than 2 weeks. Specimens collected for IgM testing greater than or equal to 2 weeks after symptom onset do not require any additional testing. For more information, please review the current clinical guidelines for Zika virus testing at: www.cdc.gov/zika/.

CPT Codes

86794

Last Updated: Monday, April 8, 2019 11:19:13 AM

Client Services: 503-413-1234