|Clinical Trial Title||Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors|
|Trial Status||Open to Enrollment|
|Trial Type||Pediatric Cancer (Oncology)|
|Specific Condition||Brain Cancer - Germ Cell Tumor|
|Description||Drugs used as chemotherapy, such as carboplatin, etoposide, and ifosfamide work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x rays to kill tumor cells. Giving chemotherapy with radiation therapy may kill more tumor cells. This phase II trial studies how well chemotherapy and radiation therapy work in treating younger patients with newly diagnosed central nervous system germ cell tumors.|
Age: > 3 years and < 21 years at the time of study enrollment
CSF Cytology: must have negative lumbar CSF cytology (must be obtained unless medically contraindicated)
Timing: patients must be enrolled on ALTE07C1 (neuropsychological/behavior late effects study) prior to enrollment on ACNS1123.
Organ Function Requirement: Adequate bone marrow, kidney, and liver function.
Central Nervous System Function:
Key Exclusions Criteria:
|Principal Investigator||Janice Olson, MD|
|Contact Name||Children's Cancer and Blood Disorders Program|