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Alliance A221505

Trial

Clinical Trial Title

Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer

Trial Status

Closed to Enrollment

Start Date

April 30, 2018

Trial Type

Cancer - Adult Oncology

Specific Condition

Breast Cancer

Description

This randomized phase III trial studies how well hypofractionated radiation therapy works in preventing recurrence in patients with stage IIa-IIIa cancer who have undergone mastectomy. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells that remain after surgery and have fewer side effects.

Eligibility Criteria

  • Histologically confirmed invasive carcinoma of the breast
  • Patient ≥ 18 years of age
  • No prior radiation therapy to the chest, neck or axilla
  • No prior history of ipsilateral breast cancer (invasive disease or DCIS)
  • No history of prior or concurrent contralateral invasive breast cancer
  • No significant post mastectomy complications requiring an unplanned re-operation or admission for IV antibiotics
  • Radiation oncologist intends to treat all target volumes described in section 7.4 and respect all normal tissues identified in section 7.4.3 in accordance with the dosimetric constraints described
  • Patient must have undergone immediate reconstruction at the time of mastectomy or be planning to undergo reconstruction within 8 months after radiation
  • No other malignancy within 5 years of registration

IRB Number

Central IRB

Principal Investigator Name

Regan Look, MD

Contact Name

Oncology Clinical Research

Phone

503-413-8199

Contact Fax

503-413-6920

Contact E-Mail

oncologyresearch@lhs.org

Last Updated: Monday, August 23, 2021 02:02:59 PM