Legacy Research Institute

Transforming medical care through science, technology, and innovation.


Researching brain function to prevent and treat disorders and improve patient care and outcomes.



Robert Stone Dow, the eminent Portland neurologist and neuroscientist and co-author with Guiseppe Moruzzi of the classic text, The Physiology and Pathology of the Cerebellum, first established the laboratories on the Good Samaritan campus in 1979 through a grant from the Murdoch Trust. An endowment from Legacy Good Samaritan Foundation established the Dow Chair in Neuroscience in 1999 in honor of Dr. Dow.

Research Focus:

The molecular and cellular mechanisms of neurological, neurodegenerative, and neuropsychiatric disorders are subjects of concentrated research. To these ends, a team of scientists with expertise in neurophysiology, neuropharmacology, biochemistry, epigenetics, and therapeutics development has been assembled to take a multidisciplinary approach to translate findings from basic research into novel therapeutics including stem cell therapies and gene therapies. 


Research funding for the labs has been provided by the National Institute of Neurological Disorders and Stroke, the National Institute of Mental Health, the US Department of Defense, the Epilepsy Foundation, and CURE (Citizens United for Research in Epilepsy). Additional funding is supplied through Legacy Health Foundations, and other philanthropic support.