Legacy Research Institute

Transforming medical care through science, technology, and innovation.

Claude F. Burgoyne, MD

Claude F. Burgoyne, M.D.

Emeritus Van Buskirk Chair for Ophthalmic Research 
Director (retired), Optic Nerve Head Research Laboratory
Devers Eye Institute, Discoveries in Sight Research Laboratories


CV (updated Jan 2024)  |  Peer Reviewed Publications (Also see CV)
Optic Nerve Head Research Laboratory  |  Discoveries in Sight Laboratories  |  Devers Eye Institute 
ORCID iD iconhttps://orcid.org/0000-0002-2765-4739

Short Bio:

Claude Burgoyne, MD is a retired Glaucoma Clinician Scientist and Emeritus Van Buskirk Chair for Ophthalmic Research at the Legacy Devers Eye Institute in Portland, Oregon. After an undergraduate Bachelor of Arts degree in Architecture and Medical School at the University of Minnesota, he pursued Ophthalmology residency training at the University of Pittsburgh and Glaucoma Fellowship training at the Wilmer Eye Institute of the Johns Hopkins Hospitals in Baltimore, MD. For twelve years he was Director of Glaucoma Services at the LSU Eye Center in New Orleans before moving to Devers in 2005. At Devers, he was Director of the Optic Nerve Head Research Laboratory (ONHRL) from 2005 to 2023.

For 25 years his laboratory was NIH funded to study the effects of aging and experimental glaucoma on the neural and connective tissues of the monkey optic nerve head within 3D histomorphometric reconstructions. This work gradually expanded to include the cell biology of connective tissue remodeling and axonal insult early in the disease. Most recently, building upon its 3D visualization capabilities, his laboratory used Optical Coherence Tomography (OCT) to structurally phenotype the deep tissues of the human optic nerve head and peri-neural canal sclera in aging, glaucoma and myopia.

Dr. Burgoyne's honors include the International Glaucoma Review AIGS Award (2004), the Lewis Rudin Glaucoma Prize (2008), the Alcon Research Institute Award (2010); the American Glaucoma Society 2015 Clinician Scientist Lectureship and the American Academy of Ophthalmology Achievement Award.

He is currently an Emeritus member of the Glaucoma Research Society for which he will give the Goldmann Lecture at its annual meeting in November of 2024. He was inducted into the American Ophthalmological Society in 2023 and is a Gold Fellow of the Association for Research in Vision and Ophthalmology, (ARVO), for which he previously served as Glaucoma Section Trustee and President.

Publication Highlights:

The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage.
Burgoyne CF, Downs JC, Bellezza AJ, Suh JK, Hart RT.
Prog Retin Eye Res. 2005 Jan;24(1):39-73.

The connective tissue phenotype of glaucomatous cupping in the monkey eye - Clinical and research implications.
Yang H, Reynaud J, Lockwood H, Williams G, Hardin C, Reyes L, Stowell C, Gardiner SK, Burgoyne CF.
Prog Retin Eye Res. 2017 Jul;59:1-52.

From clinical examination of the optic disc to clinical assessment of the optic nerve head: a paradigm change.
Chauhan BC, Burgoyne CF.
Am J Ophthalmol 2013;156:218-227 e212.

A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma.
Burgoyne CF.
Exp Eye Res. 2011 Aug;93(2):120-32

The morphological difference between glaucoma and other optic neuropathies.
Burgoyne CF.
J Neuroophthalmol. 2015 Sep;35 Suppl 1:S8-S21.

Research Interests:

  • Pathophysiology of glaucomatous optic nerve head damage
  • Optic nerve head biomechanics and blood flow
  • Optic nerve head aging
  • Optic nerve head imaging
  • Clinical examination of the optic nerve head tissues