Dr. Impey obtained a PhD in Pharmacology (Program in Neurobiology) at the University of Washington where he generated the first transgenic CREB-reporter mouse that specifically linked CREB activation to memory consolidation and other long-term brain plasticity mechanisms.
Dr. Impey joined Richard Goodman’s lab at Oregon Health & Science University (OHSU) as a post-doc in 2000. In the Goodman lab he studied the assembly and regulation of CREB- and CBP-dependent transcriptional complexes in response to neuronal activity. Dr. Impey also worked with the Dunn lab to develop a novel technology that facilitated the unbiased mapping of CREB occupancy across an entire mammalian genome. This technology was published in Cell and was among the first examples of ChIP-Seq. In subsequent work as a faculty member at OHSU, Dr. Impey used functional genomic approaches to identify microRNAs regulated by CREB, neuronal activity, and epilepsy-associated seizures. These approaches led the Impey lab to identify the microRNA 132-212 gene as a rapid response gene that promotes neuronal maturation and synaptogenesis. Hundreds of studies have subsequently implicated this microRNA gene in memory consolidation, brain plasticity, and other adaptive phenotypes.
Subsequent work by the Impey lab has focused on characterization of additional non-coding plasticity-regulated genes and the use of epigenetic profiling to identify pathways linked to brain plasticity mechanisms and neurological disease.
Dr. Impey joined the Legacy Research Institute in 2020 and continues his studies of the regulation of brain plasticity by transcriptional and epigenetic networks.
Leptin stimulates synaptogenesis in hippocampal neurons via KLF4 and SOCS3 inhibition of STAT3 signaling.
Sahin GS, Dhar M, Dillon C, Zhu M, Shiina H, Winters BD, Lambert TJ, Impey S, Appleyard SM, Wayman GA.
Mol Cell Neurosci. 2020. 106:103500.
Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals.
Su Y, Pelz C, Huang T, Torkenczy K, Wang X, Cherry A, Daniel CJ, Liang J, Nan X, Dai MS, Adey A, Impey S, Sears RC. Genes Dev. 2018. 32(21-22):1398-1419.
Bi-directional and shared epigenomic signatures following proton and 56Fe irradiation.
Impey S, Jopson, T, Pelz, C, Tafessu, A., Fareh, F., Zuloaga, D., Marzulla, T., Riparipi, L-R, Stewart, B., Rosi, S., Turker, MS, Raber, J.
Sci Rep. 2017. 7(1):10227.
Profiling status epilepticus-induced changes in hippocampal RNA expression using high-throughput RNA sequencing.
Hansen KF, Sakamoto, K, Pelz, C, Impey S, Obrietan, K
Sci Rep. 2014. 6;4:6930.
A genome-wide screen of CREB occupancy identifies the RhoA inhibitors Par6C and Rnd3 as regulators of BDNF-induced synaptogenesis.
Lesiak, A, Pelz C, Ando H, Zhu M, Davare M, Lambert TJ, Hansen KF Obrietan K, Appleyard SM, Wayman, G, Impey S
PLoS One 2013. 6;8(6):e64658.
A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis.
Vo, N., Klein, M. E., Varlamova, O., Keller, D. M., Yamamoto, T., Goodman, R. H.* and Impey, S.
Proc. Natl .Acad Sci U S A2005. 102, 16426-16431.