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Professional resources

Labs and faculty

Research labs and faculty

Research Faculty

Research Labs

Fortune Lab
Dr. Fortune’s research interests can be characterized generally as being about the anatomy and physiology of the visual system with an emphasis on understanding pathophysiology of disease and development of clinical diagnostic techniques. More specifically, Dr. Fortune’s research focus is on the pathophysiology of glaucoma and methods for detecting early-stage abnormalities of retinal ganglion cell function and sub-cellular structure in the living eye. To carry out the aims of their studies, Dr. Fortune and his research collaborators use a variety of ophthalmic imaging techniques, including optical coherence tomography (OCT), confocal scanning laser ophthalmoscopy (CSLO) and scanning laser polarimetry (SLP), as well as advanced methods for assessment of retinal function by electroretinography (ERG) and visual evoked cortical potential (VECP) testing. Their overall goal is to facilitate the translation of findings from laboratory studies to the clinical care and management of glaucoma.

Gardiner Lab
Dr. Gardiner’s research focuses on improving testing methods for glaucoma. This includes both functional testing (perimetry) and structural testing (imaging, OCT), and the way they fit together to give information about the patient’s vision, and how it may change over the next few years. He is funded by the National Institutes of Health to investigate ways to improve functional testing, making the tests more reliable and more useful. He works closely with Dr. Demirel on a longitudinal study to see how the disease progresses, and to try to predict how quickly it is likely to progress in order to better inform clinicians considering different treatment options. He also works with Dr. Burgoyne on ways to analyze the information obtained from OCT, an imaging device that is becoming widely used clinically. Thanks to his training in statistics, he helps other investigators with their studies, both in Legacy Devers Eye Institute and elsewhere in Legacy Health.

Rosenbaum Lab
The Rosenbaum Lab at Legacy Research Institute is primarily interested in the understanding of animal models of uveitis (inflammation inside the eye) and the testing of novel compounds to control inflammation in these models. The lab studies primarily endotoxin-induced uveitis in mice or rats and intraocular inflammation in rabbits secondary to killed mycobacteria, bacteria which are similar to the cause of tuberculosis. Endotoxin is derived from bacterial cell walls and is recognized by the body's "innate" immune system. The endotoxin induced uveitis model is a useful paradigm to study regulators of the innate immune response.

In addition to animal trials, the Rosenbaum lab conducts clinical trials in patients to improve the management of intraocular inflammation.





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